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Pacemaker algorithm tuned to Heart's pumping may beat standard rate response

NCT ID NCT07812935

Symptom relief Sponsor: Bartlomiej Wrobel Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are testing whether a pacemaker setting called closed-loop stimulation helps the heart rate rise more naturally during mental and physical stress compared with standard accelerometer-based pacing. The study includes adults with permanent atrial fibrillation, chronotropic incompetence, and a left bundle branch area pacemaker. Participants complete mental math, handgrip, and treadmill tests under both pacing modes, and researchers measure changes in heart rate, exercise duration, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Closed-loop stimulation pacing, a pacemaker algorithm that adjusts heart rate based on the heart's pumping dynamics
What this could lead to
If it works, this could offer a pacing option that helps people with atrial fibrillation and conduction disorders keep a more natural heart rate during daily activities and stress.
What could go wrong
This is a small, single-center study with 33 participants, so results may not apply broadly. The crossover design means each person tries both pacing modes, but the short testing period may not capture long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Jun 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Permanent atrial fibrillation * Chronotropic incompetence * Permanent pacemaker with left bundle branch area pacing (LBBAP) * Ventricular pacing burden \>50% * Ability to provide written informed consent Exclusion Criteria: * Age \<18 years * Inability or unwillingness to provide informed consent

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Conditions

The condition(s) this trial relates to.

atrial fibrillation third-degree atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation (AF) Block complete heart Chronotropic incompetence

Contacts and locations

Locations

  • Clinical Provincial Hospital No. 2 in Rzeszow

    Rzeszów, Podkarpackie Voivodeship, 35-302, Poland

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