New CAR-T therapy aims to control Hard-to-Treat multiple myeloma

NCT ID NCT04960579

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 22 times

Summary

This early-stage study tests an experimental therapy called P-BCMA-ALLO1 for people with multiple myeloma that has come back or stopped responding to standard treatments. The therapy uses donor immune cells engineered to target and kill myeloma cells. The main goals are to check safety, find the best dose, and see if it can shrink tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Advocate Aurora Health

    Park Ridge, Illinois, 66068, United States

  • Blood Marrow and Transplant Group of Georgia

    Atlanta, Georgia, 30342, United States

  • City of Hope

    Goodyear, Arizona, 85338, United States

  • City of Hope

    Chicago, Illinois, 60099, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Hackensack Meridian Health

    Hackensack, New Jersey, 07601, United States

  • Houston Methodist Research Institute

    Houston, Texas, 77030, United States

  • Mount Sinai

    New York, New York, 10029, United States

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New York, 14263, United States

  • Sarah Cannon Research Institute - Methodist Healthcare

    San Antonio, Texas, 78229, United States

  • Sarah Cannon Research Institute - St. David's South Austin Medical Center

    Austin, Texas, 78704, United States

  • University of California San Diego

    San Diego, California, 92093, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45221, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Maryland Greenebaum Comprehensive Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599-1350, United States

  • University of Oklahoma, Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104-4238, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wayne State - Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

Conditions

Explore the condition pages connected to this study.