Sickle cell drug oxbryta tracked in real life: what happened?
NCT ID NCT04930445
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study followed 265 people with sickle cell disease who were taking Oxbryta (voxelotor) as part of their normal care. Researchers wanted to see how the drug affected hemoglobin levels, sickle cell complications, and overall health over up to 5 years. The study was observational, meaning patients were not assigned to a specific treatment plan—they just took Oxbryta as their doctor prescribed. Unfortunately, the study was terminated early, so the full planned data was not collected.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oxbryta (voxelotor) tablets
What this could lead to
If successful, this registry could confirm that Oxbryta helps manage sickle cell disease in everyday settings, improving hemoglobin levels and reducing complications.
What could go wrong
The study was terminated early, so long-term data is limited. As an observational registry, it cannot prove cause and effect, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Augusta University
Augusta, Georgia, 30912, United States
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Augusta University - Clinical Trials Office (clinic)
Augusta, Georgia, 30912, United States
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Bass Center for Childhood Cancer and Blood Disorders (Stanford Lucile Packard Children's Hospital)
Palo Alto, California, 94304, United States
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Boston University Medical Center
Boston, Massachusetts, 02118, United States
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Center for Inherited Blood Disorders
Orange, California, 92868, United States
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Children's Blood and Cancer Center at Dell Children's Medical Center
Austin, Texas, 78723, United States
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Dell Children's Medical Center
Austin, Texas, 78723, United States
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Department of Pediatrics, Hematology section
Palo Alto, California, 94304, United States
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Duke University Hospital
Durham, North Carolina, 27710, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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ECU Health Medical Center
Greenville, North Carolina, 27834, United States
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ECU Health Medical Center Laboratory
Greenville, North Carolina, 27834, United States
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East Carolina University
Greenville, North Carolina, 27834-4300, United States
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Foundation for Sickle Cell Disease Research
Hollywood, Florida, 33023, United States
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INOVA Health
Falls Church, Virginia, 22042-2325, United States
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Inova Schar Cancer Institute
Fairfax, Virginia, 22031, United States
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Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Medical University of South Carolina Shawn Jenkins Women's and Children's Hospital
Charleston, South Carolina, 29425, United States
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Mississippi Center for Advanced Medicine
Madison, Mississippi, 39110, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Nemours Alfred I duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Nemours Children's Health, Wilmington
Wilmington, Delaware, 19803, United States
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Nemours Children's Specialty Care
Jacksonville, Florida, 32207, United States
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Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Stanford Children's Hospital
Palo Alto, California, 94304, United States
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UPMC Montefiore Hospital
Pittsburgh, Pennsylvania, 14213, United States
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UPMC Presbyterian
Pittsburgh, Pennsylvania, 15213, United States
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UPMC Sickle Cell Center
Pittsburgh, Pennsylvania, 15123, United States
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University of California, San Diego
La Jolla, California, 92093-0987, United States
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University of Connecticut Health
Farmington, Connecticut, 06030-1163, United States
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University of Connecticut Health
Farmington, Connecticut, 06030, United States
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University of Illinois Hospital and Health Sciences System
Chicago, Illinois, 60612, United States
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University of Illinois Hospital and Health Sciences System(UI Health)
Chicago, Illinois, 60612, United States
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University of Illinois at Chicago (UIC) Clinical Research Center
Chicago, Illinois, 60612, United States
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University of Illinois at Chicago (UIC) Sickle Cell Center
Chicago, Illinois, 60612, United States
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University of Maryland Medical Center
College Park, Maryland, 21201, United States
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University of Miami Hospital
Miami, Florida, 33136, United States
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University of Pittsburgh Medical Center (UPMC)
Pittsburgh, Pennsylvania, 15261, United States
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University of South Alabama
Mobile, Alabama, 36617, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States