Sickle cell drug oxbryta tracked in real life: what happened?

NCT ID NCT04930445

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 265 people with sickle cell disease who were taking Oxbryta (voxelotor) as part of their normal care. Researchers wanted to see how the drug affected hemoglobin levels, sickle cell complications, and overall health over up to 5 years. The study was observational, meaning patients were not assigned to a specific treatment plan—they just took Oxbryta as their doctor prescribed. Unfortunately, the study was terminated early, so the full planned data was not collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oxbryta (voxelotor) tablets
What this could lead to: If successful, this registry could confirm that Oxbryta helps manage sickle cell disease in everyday settings, improving hemoglobin levels and reducing complications.
What could go wrong: The study was terminated early, so long-term data is limited. As an observational registry, it cannot prove cause and effect, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE

Contacts and locations

Locations

Augusta University

Augusta, Georgia, 30912, United States
Augusta University - Clinical Trials Office (clinic)

Augusta, Georgia, 30912, United States
Bass Center for Childhood Cancer and Blood Disorders (Stanford Lucile Packard Children's Hospital)

Palo Alto, California, 94304, United States
Boston University Medical Center

Boston, Massachusetts, 02118, United States
Center for Inherited Blood Disorders

Orange, California, 92868, United States
Children's Blood and Cancer Center at Dell Children's Medical Center

Austin, Texas, 78723, United States
Dell Children's Medical Center

Austin, Texas, 78723, United States
Department of Pediatrics, Hematology section

Palo Alto, California, 94304, United States
Duke University Hospital

Durham, North Carolina, 27710, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
ECU Health Medical Center

Greenville, North Carolina, 27834, United States
ECU Health Medical Center Laboratory

Greenville, North Carolina, 27834, United States
East Carolina University

Greenville, North Carolina, 27834-4300, United States
Foundation for Sickle Cell Disease Research

Hollywood, Florida, 33023, United States
INOVA Health

Falls Church, Virginia, 22042-2325, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medical University of South Carolina Shawn Jenkins Women's and Children's Hospital

Charleston, South Carolina, 29425, United States
Mississippi Center for Advanced Medicine

Madison, Mississippi, 39110, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Nemours Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Nemours Children's Health, Wilmington

Wilmington, Delaware, 19803, United States
Nemours Children's Specialty Care

Jacksonville, Florida, 32207, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Stanford Children's Hospital

Palo Alto, California, 94304, United States
UPMC Montefiore Hospital

Pittsburgh, Pennsylvania, 14213, United States
UPMC Presbyterian

Pittsburgh, Pennsylvania, 15213, United States
UPMC Sickle Cell Center

Pittsburgh, Pennsylvania, 15123, United States
University of California, San Diego

La Jolla, California, 92093-0987, United States
University of Connecticut Health

Farmington, Connecticut, 06030-1163, United States
University of Connecticut Health

Farmington, Connecticut, 06030, United States
University of Illinois Hospital and Health Sciences System

Chicago, Illinois, 60612, United States
University of Illinois Hospital and Health Sciences System(UI Health)

Chicago, Illinois, 60612, United States
University of Illinois at Chicago (UIC) Clinical Research Center

Chicago, Illinois, 60612, United States
University of Illinois at Chicago (UIC) Sickle Cell Center

Chicago, Illinois, 60612, United States
University of Maryland Medical Center

College Park, Maryland, 21201, United States
University of Miami Hospital

Miami, Florida, 33136, United States
University of Pittsburgh Medical Center (UPMC)

Pittsburgh, Pennsylvania, 15261, United States
University of South Alabama

Mobile, Alabama, 36617, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.