Hope for Platinum-Resistant ovarian cancer: new pill takes on chemo

NCT ID NCT07214779

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 10 times

Summary

This Phase 3 trial tests a new oral drug, INCB123667, against standard chemotherapy in 466 people with platinum-resistant ovarian cancer that overexpresses cyclin E1. The goal is to see if the new drug can delay cancer growth or improve survival. Participants will be randomly assigned to receive either the new drug or one of several chemotherapy options chosen by their doctor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INCB123667 (oral tablet)
What this could lead to: If successful, this could offer a new treatment option for people with platinum-resistant ovarian cancer who have limited choices.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The drug may not work better than chemotherapy or could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube serous adenocarcinoma ovarian cancer ovarian carcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Aichi Cancer Center
RECRUITING

Nagoya, 464-8681, Japan
Alaska Womens Cancer Care Akwcc
NOT_YET_RECRUITING

Anchorage, Alaska, 99508, United States
Allegheny Health Network- West Penn Hospital
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Aou Policlinico S. Orsola-Malpighi
NOT_YET_RECRUITING

Bologna, 40138, Italy
Asan Medical Center
NOT_YET_RECRUITING

Seoul, 05505, South Korea
Atrium Health Wake Forest Baptist
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Ausl Di Placenza Ospedale Guglielmo Da Saliceto
NOT_YET_RECRUITING

Piacenza, 29121, Italy
Az Groeninge
NOT_YET_RECRUITING

Kortrijk, 08500, Belgium
Az Maria Middelares Gent
NOT_YET_RECRUITING

Ghent, 09000, Belgium
Azienda Ospedaliera Ordine Mauriziano Di Torino
NOT_YET_RECRUITING

Torino, 10128, Italy
Azienda Ospedaliero-Universitaria Friuli Centrale
NOT_YET_RECRUITING

Udine, 33100, Italy
Azienda Sanitaria Locale (Asl) Cn2 Alba-Bra
NOT_YET_RECRUITING

Alba, 12051, Italy
Azienda Socio Santaria Territoriale de Lecco - Ospedale A. Manzoni
NOT_YET_RECRUITING

Lecco, 23900, Italy
Azienda Ulss 3 Serenissima - Ospedale Di Mirano
NOT_YET_RECRUITING

Mirano, 30035, Italy
Billings Clinic
RECRUITING

Billings, Montana, 59101, United States
Brcr Global
NOT_YET_RECRUITING

Miramar, Florida, 33027, United States
Brcr Global - Hato Rey
NOT_YET_RECRUITING

San Juan, 00917, Puerto Rico
Brcr Global - Yauco
NOT_YET_RECRUITING

Yauco, PR, 00698, Puerto Rico
Carle Cancer Center
NOT_YET_RECRUITING

Effingham, Illinois, 62401-2006, United States
Cedars Cancer Centre - McGill University Health Centre (Muhc) - Glen Site
NOT_YET_RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Center of Hope
NOT_YET_RECRUITING

Reno, Nevada, 89511, United States
Centre Antoine Laccassagne
NOT_YET_RECRUITING

Nice, 06189, France
Centre Eugene Marquis
NOT_YET_RECRUITING

Rennes, 35042, France
Centre Hospitalier Departemental de Vendee, Hopital de La-Roche-Sur-Yon Les Oudairies
NOT_YET_RECRUITING

La Roche-sur-Yon, 85925, France
Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit
RECRUITING

Lausanne, 01011, Switzerland
Centre Hospitalier Universitaire de Grenoble- Hopital Albert Michallon
NOT_YET_RECRUITING

La Tronche, 38700, France
Centro Di Riferimento Oncologico Di Aviano
NOT_YET_RECRUITING

Aviano, 33081, Italy
Ch Davignon - Hopital Henri Duffaut
NOT_YET_RECRUITING

Avignon, 84902, France
Cha Ilsan Medical Center
NOT_YET_RECRUITING

Goyang-si, 10414, South Korea
Cha University Bundang Cha Medical Center
NOT_YET_RECRUITING

Seongnam-si, 13520, South Korea
Charite Campus Virchow
NOT_YET_RECRUITING

Berlin, 13353, Germany
Chris O'Brien Lifehouse Hospital
NOT_YET_RECRUITING

Camperdown, New South Wales, 02050, Australia
City of Hope - Chicago Cancer Center
NOT_YET_RECRUITING

Zion, Illinois, 60099, United States
City of Hope Medical Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Clatterbridge Cancer Center
RECRUITING

Liverpool, L7 8YA, United Kingdom
Cleveland Clinic Foundation
NOT_YET_RECRUITING

Cleveland, Ohio, 44195-0001, United States
Clinica Universidad de Navarra
NOT_YET_RECRUITING

Madrid, 28022, Spain
Clinique Pole Sante Leonard de Vinci
NOT_YET_RECRUITING

Chambray-lès-Tours, 37170, France
Clinique Tivoli
NOT_YET_RECRUITING

Bordeaux, 33000, France
Cliniques Universitaires St Luc Ucl
NOT_YET_RECRUITING

Brussels, B-1200, Belgium
Corporacio Sanitaria Universitaria Parc Tauli
NOT_YET_RECRUITING

Sabadell, 08208, Spain
Cross Cancer Insititute
NOT_YET_RECRUITING

Edmonton, Alberta, T6G-1Z2, Canada
East Carolina University
NOT_YET_RECRUITING

Greenville, North Carolina, 27834, United States
Eastern Health-Box Hill Hospital
NOT_YET_RECRUITING

Box Hill, Victoria, 03128, Australia
Erlanger Health, Inc.
RECRUITING

Chattanooga, Tennessee, 37403, United States
Ewha Womans University Mokdong Hospital
NOT_YET_RECRUITING

Seoul, 07985, South Korea
Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Gdanski Uniwersytet Medyczny
NOT_YET_RECRUITING

Gdansk, 80-214, Poland
Georgia Cancer Center
NOT_YET_RECRUITING

Augusta, Georgia, 30912, United States
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Hokkaido University Hospital
NOT_YET_RECRUITING

Sapporo, 060-8648, Japan
Holy Cross Hospital
NOT_YET_RECRUITING

Silver Spring, Maryland, 20910, United States
Hopital Prive Jean Mermoz
NOT_YET_RECRUITING

Lyon, 69008, France
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
NOT_YET_RECRUITING

Brussels, 01070, Belgium
Hopital de Hautepierre
NOT_YET_RECRUITING

Strasbourg, 67098, France
Hopitaux Universitaires de Geneve (Hug) (Hopital Cantonal)
RECRUITING

Geneva, 01205, Switzerland
Hospital Clinic de Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Tenon
NOT_YET_RECRUITING

Paris, 75970, France
Hospital Universitari Son Espases
NOT_YET_RECRUITING

Palma, 07120, Spain
Hospital Universitario Central de Asturias
NOT_YET_RECRUITING

Oviedo, 33011, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Del Rocio
NOT_YET_RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen de La Victoria
NOT_YET_RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen de Valme
NOT_YET_RECRUITING

Seville, 41014, Spain
Hospital Universitario de Alava
NOT_YET_RECRUITING

Alava, 01009, Spain
Humanitas San Pio X
NOT_YET_RECRUITING

Milan, 20159, Italy
Hyogo Cancer Center
NOT_YET_RECRUITING

Akashi-shi, 673-8558, Japan
Ico-Badalona
NOT_YET_RECRUITING

Badalona, 89016, Spain
Icon Cancer Care - Townsville
RECRUITING

Townsville, Queensland, 04812, Australia
Inova Schar Cancer Institute
NOT_YET_RECRUITING

Fairfax, Virginia, 22031, United States
Institut Gustave Roussy-Gustave Roussy Cancer Center -Ditep
NOT_YET_RECRUITING

Villejuif, 94805, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, 13009, France
Iov - Istituto Oncologico Veneto Irccs
NOT_YET_RECRUITING

Padova, 35128, Italy
Irccs Fondazione Policlinico San Matteo
NOT_YET_RECRUITING

Pavia, 27100, Italy
Irccs Istituto Nazionale Tumori Regina Elena (Irccs Regina Elena National Cancer Institute)
NOT_YET_RECRUITING

Roma, 00144, Italy
Istituto Nazionale Tumori Irccs Fondazione Pascale
NOT_YET_RECRUITING

Naples, 80131, Italy
Iwate Medical University Hospital
RECRUITING

Shiwa-gun, 028-3695, Japan
Johannes Wesling Klinikum Minden
NOT_YET_RECRUITING

Minden, 32429, Germany
Jps Health Network
NOT_YET_RECRUITING

Fort Worth, Texas, 76104, United States
Kantonsspital Frauenfeld
RECRUITING

Frauenfeld, 08501, Switzerland
Kantonsspital Graubunden
NOT_YET_RECRUITING

Chur, 07000, Switzerland
Keimyung University Dongsan Hospital
NOT_YET_RECRUITING

Daegu, 42601, South Korea
Kliniken Essen-Mitte
NOT_YET_RECRUITING

Essen, 45136, Germany
Klinikum Kassel Gmbh
NOT_YET_RECRUITING

Kassel, 34125, Germany
Konkuk University Medical Center
NOT_YET_RECRUITING

Seoul, 05030, South Korea
Korea University Anam Hospital
NOT_YET_RECRUITING

Seoul, 02841, South Korea
Korea University Ansan Hospital
NOT_YET_RECRUITING

Ansan-si, 15355, South Korea
Kurume University Hospital
NOT_YET_RECRUITING

Kurume, 830-0011, Japan
Levine Cancer Center
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
London Health Sciences Centre
NOT_YET_RECRUITING

London, Ontario, N6A 5W9, Canada
Maine Center For Cancer Medicine
NOT_YET_RECRUITING

Scarborough, Maine, 04074, United States
Mater Hospital Brisbane
NOT_YET_RECRUITING

South Brisbane, Queensland, 04101, Australia
Mater Misericordiae University Hospital
NOT_YET_RECRUITING

Dublin, D07 R2WY, Ireland
Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii
NOT_YET_RECRUITING

Siedlce, 08-110, Poland
Mercy Hospital St. Louis - David C. Pratt Cancer Center
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Mount Vernon Cancer Centre
NOT_YET_RECRUITING

Northwood, HA6 2RN, United Kingdom
Musgrove Park Hospital - Somerset Nhs Foundation Trust
RECRUITING

Taunton, TA1 5DA, United Kingdom
National Cancer Center
NOT_YET_RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital
NOT_YET_RECRUITING

Tokyo, 104-0045, Japan
Nki-Avl (Nederlands Kanker Instituut-Anthonie Van Leeuwenhoek)
NOT_YET_RECRUITING

Amsterdam, 1066 CX, Netherlands
Northampton General Hospital - Northampton General Hospital Nhs Trust
NOT_YET_RECRUITING

Northampton, NN1 5BD, United Kingdom
Northshore University Health System-Evanston Hospital
NOT_YET_RECRUITING

Evanston, Illinois, 60201, United States
Novant Health Oncology Specialists
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Novant Presbyterian Hospital
RECRUITING

Charlotte, North Carolina, 28204, United States
Ohio Health Research Institute
NOT_YET_RECRUITING

Columbus, Ohio, 43214, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan
Ospedale Ca' Foncello
NOT_YET_RECRUITING

Treviso, 31100, Italy
Ospedale Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
Ospedale Regionale Di Bellinzona
NOT_YET_RECRUITING

Bellinzona, 06500, Switzerland
Ospedale San Raffaele Irccs
NOT_YET_RECRUITING

Milan, 20132, Italy
Ospedale Santa Maria Delle Croci
NOT_YET_RECRUITING

Ravenna, 48121, Italy
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
NOT_YET_RECRUITING

Rome, 00168, Italy
Promedica Flower Hospital
NOT_YET_RECRUITING

Sylvania, Ohio, 43560, United States
Providence Cancer Institute Franz Clinic
NOT_YET_RECRUITING

Portland, Oregon, 97213, United States
Providence Medical Foundation
NOT_YET_RECRUITING

Fullerton, California, 92835, United States
Radboud University Medical Center
RECRUITING

Nijmegen, 6525 GA, Netherlands
Royal Marsden Hospital - London
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital - Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Surrey County Hospital - Royal Surrey County Hospital Nhs Foundation Trust
RECRUITING

Guildford, GU2 7XX, United Kingdom
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, 350-1298, Japan
Samsung Changwon Hospital
NOT_YET_RECRUITING

Changwon-si, 51353, South Korea
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, 06351, South Korea
Sanford Cancer Center-Sioux Falls
NOT_YET_RECRUITING

Sioux Falls, South Dakota, 57104-8805, United States
Sapporo Medical University Hospital
RECRUITING

Sapporo, 060-8543, Japan
Seoul National University Bundang Hospital (Snubh)
NOT_YET_RECRUITING

Seongnam-si, 13620, South Korea
Seoul National University Hospital
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Seoul St. Mary'S Hospital
NOT_YET_RECRUITING

Seoul, 06591, South Korea
Severance Hospital Yonsei University Health System
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Shikoku Cancer Center
RECRUITING

Matsuyama, 791-0280, Japan
Shizuoka Cancer Center
NOT_YET_RECRUITING

Shizuoka, 411-8777, Japan
Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Sir Mortimer B. Davis - Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Ss Antonio & Biagio and C. Arrigo Hospital
NOT_YET_RECRUITING

Alessandria, 15121, Italy
St Elizabeth Healthcare
NOT_YET_RECRUITING

Edgewood, Kentucky, 41017, United States
St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
NOT_YET_RECRUITING

Leeds, LS9 7TF, United Kingdom
St. James Hospital
NOT_YET_RECRUITING

Dublin, D08 NHY1, Ireland
St. Vincent'S University Hospital
NOT_YET_RECRUITING

Dublin, D04 Y8V0, Ireland
Swietokrzyskie Centrum Onkologii Spzoz
NOT_YET_RECRUITING

Kielce, 25-734, Poland
Texas Oncology Cancer Center
NOT_YET_RECRUITING

Sugar Land, Texas, 77479, United States
Texas Oncology-Abilene
NOT_YET_RECRUITING

Abilene, Texas, 79606, United States
The Cancer Institute Hospital of Jfcr
NOT_YET_RECRUITING

Kōtoku, 135-8550, Japan
The Christie Nhs Foundation Trust
RECRUITING

Manchester Greater, M204BX, United Kingdom
The Jikei University Hospital
RECRUITING

Minatoku, 105-8471, Japan
The Wollongong Hospital
NOT_YET_RECRUITING

Wollongong, New South Wales, 02500, Australia
Tohoku University Hospital
RECRUITING

Sendai, 980-8574, Japan
Tom Baker Cancer Center-Alberta Health Services (Ahs) - University of Calgary
NOT_YET_RECRUITING

Calgary, Alberta, T2N 4N2, Canada
UZ GENT
NOT_YET_RECRUITING

Ghent, 09000, Belgium
Uci Health Chao Family Comprehensive Cancer Center
NOT_YET_RECRUITING

Orange, California, 92868-3298, United States
Universitaetsklinikum Bonn
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Dresden
NOT_YET_RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Tuebingen (Ukt)
NOT_YET_RECRUITING

Tübingen, 72076, Germany
Universitair Medisch Centrum Utrecht (Umc Utrecht)
NOT_YET_RECRUITING

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Leuven
NOT_YET_RECRUITING

Leuven, 03000, Belgium
Universitatsklinikum Schleswig Holstein
NOT_YET_RECRUITING

Kiel, 24105, Germany
University College Hospital Galway
NOT_YET_RECRUITING

Galway, H91 YR71, Ireland
University College London Hospitals - University College London Hospitals Nhs Foundation Trust
RECRUITING

London, NW1 2BU, United Kingdom
University Health Network (Uhn) - Princess Margaret Cancer Centre
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University Hospital Waterford
NOT_YET_RECRUITING

Waterford, X91 ER8E, Ireland
University Hospital of Zurich
NOT_YET_RECRUITING

Zurich, 08032, Switzerland
University Medical Center Groningen
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
University of Arizona Cancer Center
NOT_YET_RECRUITING

Tucson, Arizona, 85724-5002, United States
University of California, San Diego-Moores Cancer Center
NOT_YET_RECRUITING

La Jolla, California, 92037, United States
University of Colorado Cancer Center
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
University of Pittsburgh Cancer Institute Cancer Services
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Health Science Center San Antonio
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
University of Virginia Health System
NOT_YET_RECRUITING

Charlottesville, Virginia, 22908, United States
Universitätsmedizin Mannheim
NOT_YET_RECRUITING

Mannheim, 68167, Germany
Uniwersytecki Szpital Kliniczny Nr 2 Pomorskiego Uniwersytetu Medycznego W Szczecinie
NOT_YET_RECRUITING

Szczecin, 70-111, Poland
Uniwersytecki Szpital Kliniczny W Bialymstoku
NOT_YET_RECRUITING

Bialystok, 15-276, Poland
Unm Comprehensive Cancer Center
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87131, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Velindre Nhs Trust, Velindre Cancer Centre
NOT_YET_RECRUITING

Cardiff, CF14 2TL, United Kingdom
Ventura County Hematology Oncology Specialists-Oxnard
NOT_YET_RECRUITING

Oxnard, California, 93030, United States
Virginia Mason Medical Center
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States
Wellspan Gynecologic Oncology
NOT_YET_RECRUITING

York, Pennsylvania, 17403, United States
Winship Cancer Institute At Emory University
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Women'S Cancer Care
NOT_YET_RECRUITING

Covington, Louisiana, 70433, United States
Women'S Cancer Center of Nevada
NOT_YET_RECRUITING

Las Vegas, Nevada, 89106, United States

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