Can a simple ultrasound catch ovarian cancer early?

NCT ID NCT04473833

Recruiting now Diagnosis Sponsor: John R van Nagell Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is testing whether yearly transvaginal ultrasounds can improve ovarian cancer screening in women at intermediate to high risk. Researchers aim to reduce false alarms while still catching real cancers. Up to 65,000 women in Kentucky will be screened over time to see if this approach works better than current methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transvaginal ultrasonography (TVS)
What this could lead to: If successful, this could make ovarian cancer screening more accurate, catching cancers earlier and reducing unnecessary surgeries from false alarms.
What could go wrong: This is a screening study, not a treatment trial. It may not reduce deaths from ovarian cancer, and false positives could still cause anxiety or unnecessary procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States

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