Could a monthly ring replace the pill? new study tests Hormone-Free contraceptive

NCT ID NCT06127199

Recruiting now Disease control Sponsor: Daré Bioscience, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing Ovaprene, a non-hormonal vaginal ring worn for a month at a time to prevent pregnancy. About 656 women aged 18–40 will use the ring for up to 13 menstrual cycles. Researchers will track how many become pregnant and how safe and acceptable the ring is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ovaprene non-hormonal intravaginal ring
What this could lead to: If successful, Ovaprene could offer a hormone-free, user-controlled contraceptive option that is placed monthly.
What could go wrong: This is a single-arm, open-label study without a comparison group, so effectiveness may be overestimated. The ring may not prevent pregnancy as well as hormonal methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONTRACEPTION

Contacts and locations

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Locations

Amicis Research Center
ACTIVE_NOT_RECRUITING

Newhall, California, 91321, United States
Boston Medical Center
COMPLETED

Boston, Massachusetts, 02118, United States
Carolina Women's Research and Wellness Center
COMPLETED

Durham, North Carolina, 27713, United States
Case Western
COMPLETED

Cleveland, Ohio, 44106, United States
Columbia University
COMPLETED

New York, New York, 10032, United States
Del Sol Research Management, LLC
RECRUITING

Tucson, Arizona, 85715, United States
Eastern Virginia Medical School
COMPLETED

Norfolk, Virginia, 23507, United States
Einstein College of Medicine
COMPLETED

The Bronx, New York, 10461, United States
Emory University
COMPLETED

Atlanta, Georgia, 30322, United States
Essential Access Health
COMPLETED

Los Angeles, California, 90010, United States
Essential Health Access (Berkeley)
COMPLETED

Berkeley, California, 94710, United States
Magee-Women's Hospital
COMPLETED

Pittsburgh, Pennsylvania, 15213, United States
MomDoc Women's Health Research
ACTIVE_NOT_RECRUITING

Scottsdale, Arizona, 85251, United States
Oregon Health and Science University
COMPLETED

Portland, Oregon, 97239, United States
Praetorian Pharmaceutical Research, LLC
ACTIVE_NOT_RECRUITING

Marrero, Louisiana, 70072, United States
Precision Trials AZ
RECRUITING

Phoenix, Arizona, 85032, United States
Rutgers Medical Center
COMPLETED

Newark, New Jersey, 07103, United States
Seattle Clinical Research Center
RECRUITING

Seattle, Washington, 98104, United States

Contact Email: •••••@•••••
The Johns Hopkins University
COMPLETED

Baltimore, Maryland, 21224, United States
University of California at Davis
COMPLETED

Sacramento, California, 95817, United States
University of California, San Francisco
WITHDRAWN

San Francisco, California, 94143, United States
University of Cincinnati
COMPLETED

Cincinnati, Ohio, 45267, United States
University of Colorado Denver
COMPLETED

Aurora, Colorado, 80045, United States
University of Hawaii
COMPLETED

Honolulu, Hawaii, 96826, United States
University of Pennsylvania Penn Obstetric Gynecology Associates
COMPLETED

Philadelphia, Pennsylvania, 19104, United States
University of Utah
COMPLETED

Salt Lake City, Utah, 84132, United States
Washington University
COMPLETED

St Louis, Missouri, 63110, United States

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