New drug combo aims to strengthen brittle bones and prevent fractures

NCT ID NCT03735537

Completed Disease control Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

Summary

This study tested a new treatment approach for adults with osteogenesis imperfecta (OI), a genetic condition that causes brittle bones and frequent fractures. Researchers wanted to see if a two-year course of a bone-building drug (teriparatide) followed by a single infusion of a bone-strengthening drug (zoledronic acid) could reduce the number of people who experience fractures compared to standard care. The trial involved 350 adults with OI who were randomly assigned to receive either the new treatment sequence or continue with their usual care.

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Contacts and locations

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Locations

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZR, United Kingdom
Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Bristol Royal Infirmary

Bristol, NS2 8HW, United Kingdom
Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
Guy's and St Thomas' Hospital

London, SE1 9RT, United Kingdom
Haywood Community Hospital

Stoke-on-Trent, ST6 7AG, United Kingdom
James Cook University Hospital

Middlesbrough, PS4 3BW, United Kingdom
Leicester Royal Infirmary

Leicester, LE1 5WW, United Kingdom
Llandough University Hospital

Llandough, CF64 2XX, United Kingdom
Manchester Royal Infirmary

Manchester, M13 9WL, United Kingdom
Ninewells Hospital

Dundee, DD1 9SY, United Kingdom
Northern General Hospital

Sheffield, S5 7AU, United Kingdom
Nottingham City Hospital

Nottingham, NG5 1PD, United Kingdom
Nuffield Orthopaedic Centre

Oxford, OX3 7HE, United Kingdom
Queen Elizabeth Hospital

Birmingham, B15 2TH, United Kingdom
Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom
Royal Liverpool Hospital and Aintree Hospital

Liverpool, L7 8XP, United Kingdom
Royal National Orthopaedic Hospital

Stanmore, HA7 4LP, United Kingdom
Royal Victoria Hospital

Belfast, BT12 6BA, United Kingdom
St Vincent's Hospital

Dublin, 4, Ireland
University Hospital Southampton

Southampton, S016 6YD, United Kingdom
Western General Hospital

Edinburgh, EH4 2XU, United Kingdom
Wishaw General Hospital

Wishaw, ML2 0DP, United Kingdom

Conditions

Explore the condition pages connected to this study.

OSTEOGENESIS IMPERFECTA