New hope for stage III lung cancer: targeted pill may delay progression

NCT ID NCT03521154

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This phase 3 study tests whether the targeted drug osimertinib can keep stage III EGFR-mutant lung cancer from progressing after initial chemoradiation. About 216 participants will receive either osimertinib or a placebo daily until their cancer worsens or side effects become unacceptable. The main goal is to see how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Osimertinib (a targeted drug that blocks EGFR mutations in cancer cells)
What this could lead to: If successful, this could offer a new maintenance option to delay cancer progression for people with stage III EGFR-mutant lung cancer after chemoradiation.
What could go wrong: This is a phase 3 trial, but results are not yet final. The drug may not significantly improve survival, and side effects like lung inflammation or skin reactions are possible.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER STAGE III

Contacts and locations

Locations

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Duarte, California, 91010, United States
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Atlanta, Georgia, 30322, United States
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Florham Park, New Jersey, 07932, United States
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Salt Lake City, Utah, 84106, United States
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Madison, Wisconsin, 53792, United States
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Ciudad Autónoma de Bs. As., 1426, Argentina
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Ciudad Autónoma de Bs. As., C1199ABB, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, 2000, Argentina
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San Salvador de Jujuy, 4600, Argentina
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Barretos, 14784-400, Brazil
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Curitiba, 81520-060, Brazil
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Florianópolis, 88034-000, Brazil
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Fortaleza, 60336-045, Brazil
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Porto Alegre, 90160-093, Brazil
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Porto Alegre, 90610-000, Brazil
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Ribeirão Preto, 14021-636, Brazil
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São Paulo, 01221-0100, Brazil
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São Paulo, 01246-000, Brazil
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Beijing, 100021, China
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Beijing, 100730, China
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Changchun, 130000, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Hangzhou, 310006, China
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Hangzhou, 310022, China
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Jinan, 250117, China
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Linhai, 317000, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Ürümqi, 830099, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Gyöngyös - Mátraháza, 3200, Hungary
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Pécs, 7623, Hungary
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Bangalore, 560068, India
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Gurgaon, 122001, India
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Hubli, 580025, India
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Karamsad, 388325, India
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Kolkata, 700160, India
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Nashik, 422002, India
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New Delhi, 110063, India
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New Delhi, 110085, India
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New Delhi, 11029, India
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Hiroshima, 734-8551, Japan
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Kanazawa, 920-8641, Japan
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Kashiwa, 227-8577, Japan
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Nagoya, 460-0001, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakaishi, 591-8555, Japan
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Sapporo, 003-0804, Japan
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Sayama, 589-8511, Japan
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Sendai, 981-0914, Japan
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Shinjuku-ku, 160-0023, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 241-8515, Japan
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George Town, 10450, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 46050, Malaysia
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Mérida, 97134, Mexico
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Lima, LIMA 31, Peru
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Lima, Lima 32, Peru
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Lima, LIMA 34, Peru
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Lima, LIMA 41, Peru
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San Isidro, 27, Peru
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Kazan', 420029, Russia
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Kostroma, 156005, Russia
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Moscow, 121205, Russia
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Novisibirsk, 630082, Russia
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Obninsk, 249036, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197758, Russia
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Ufa, 450054, Russia
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Cheongju-si, 28644, South Korea
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Incheon, 21565, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08003, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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San Sebastián, 20014, Spain
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Seville, 41009, Spain
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Valencia, 46009, Spain
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Kaohsiung City, 83301, Taiwan
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Taichung, 402, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 00333, Taiwan
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Lampang, 52000, Thailand
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Mueang, 50200, Thailand
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Adana, 01120, Turkey (Türkiye)
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Adapazarı, 54290, Turkey (Türkiye)
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Ankara, 06280, Turkey (Türkiye)
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Ankara, 6200, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Istanbul, 34030, Turkey (Türkiye)
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Istanbul, 34854, Turkey (Türkiye)
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Izmir, 35620, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam

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