Real-World study tracks osimertinib combo for lung cancer

NCT ID NCT06538038

Recruiting now Knowledge-focused Sponsor: PrECOG, LLC. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is watching how patients with EGFR-mutated non-small cell lung cancer do when they receive standard treatment with osimertinib (Tagrisso) alone or with chemotherapy in routine medical practice. About 538 people with advanced lung cancer will be followed to see how long they live without the cancer getting worse and overall survival. The goal is to gather real-world data on safety and effectiveness outside of a clinical trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: osimertinib (Tagrisso) with or without chemotherapy (cisplatin, carboplatin, pemetrexed)
What this could lead to: If successful, this study could help doctors understand which patients benefit most from adding chemotherapy to osimertinib in routine practice.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. It won't prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPIDERMAL GROWTH FACTOR RECEPTOR GENE MUTATION NON-SMALL CELL LUNG CANCER STAGE III LUNG CANCER STAGE IV LUNG CANCER

Contacts and locations

Locations

AHC Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States
Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Advocate Christ Medical Center
RECRUITING

Oak Lawn, Illinois, 60453, United States
Advocate Good Shepherd Hospital
RECRUITING

Barrington, Illinois, 60010, United States
Advocate Illinois Masonic Medical Center
RECRUITING

Chicago, Illinois, 60657, United States
Advocate Lutheran General Hospital
RECRUITING

Park Ridge, Illinois, 60068, United States
Advocate South Suburban Hospital
RECRUITING

Hazel Crest, Illinois, 60429, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Atlantic Health Cancer Consortium Community Oncology Research Program
RECRUITING

Morristown, New Jersey, 07960, United States
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005, United States
Aultman
RECRUITING

Canton, Ohio, 44710, United States
Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States
Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States
Aurora NCORP
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's South Shore
RECRUITING

Cudahy, Wisconsin, 53110, United States
Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center
RECRUITING

Milwaukee, Wisconsin, 53227, United States
Baptist Cancer Center - Grenada
RECRUITING

Grenada, Mississippi, 38901, United States
Baptist Memorial Hospital and Cancer Center - Collierville
RECRUITING

Collierville, Tennessee, 38017, United States
Baptist Memorial Hospital and Cancer Center - Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States
Baptist Memorial Hospital and Cancer Center - Golden Triangle
RECRUITING

Columbus, Mississippi, 39705, United States
Baptist Memorial Hospital and Cancer Center - Memphis
RECRUITING

Memphis, Tennessee, 38120, United States
Baptist Memorial Hospital and Cancer Center - Oxford
RECRUITING

Oxford, Mississippi, 38655, United States
Baptist Memorial Hospital and Cancer Center - Union
RECRUITING

New Albany, Mississippi, 38652, United States
Baptist Memorial Hospital for Women
RECRUITING

Memphis, Tennessee, 38120, United States
Bayhealth
RECRUITING

Dover, Delaware, 19901, United States
Cambridge Medical Center
RECRUITING

Cambridge, Minnesota, 55008, United States
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States
Carle Founation Hospital
RECRUITING

Urbana, Illinois, 61801, United States
Community Medical Center
RECRUITING

Scranton, Pennsylvania, 18510, United States
Einstein Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19141, United States
Fairview Clinics and Surgery Center Maple Grove
RECRUITING

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
RECRUITING

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
RECRUITING

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
FirstHealth of the Carolinas-Moore Regional Hospital
RECRUITING

Pinehurst, North Carolina, 28374, United States
Fowler Family Cancer Center - Jonesboro
RECRUITING

Jonesboro, Arkansas, 72401, United States
Geisinger Cancer Services-Pottsville
RECRUITING

Pottsville, Pennsylvania, 17901, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton
RECRUITING

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group
RECRUITING

State College, Pennsylvania, 16801, United States
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States
Good Samaritan University Hospital
RECRUITING

West Islip, New York, 11795, United States
Greater Baltimore Medical Center
RECRUITING

Baltimore, Maryland, 21204, United States
Gundersen Lutheran Medical Foundation
RECRUITING

La Crosse, Wisconsin, 54601, United States
Health Partners Inc.
RECRUITING

Minneapolis, Minnesota, 55454, United States
Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States
JPS Oncology & Infusion Center
RECRUITING

Fort Worth, Texas, 76104, United States
Jackson Oncology Associates PLLC
RECRUITING

Jackson, Mississippi, 39202, United States
Jefferson Torresdale Hospital
RECRUITING

Philadelphia, Pennsylvania, 19114, United States
John H Stroger Jr Hospital of Cook County
RECRUITING

Chicago, Illinois, 60612, United States
John Muir Health
RECRUITING

Walnut Creek, California, 94598, United States
Lakeview Hospital
RECRUITING

Stillwater, Minnesota, 55082, United States
Lankenau Medical Center
RECRUITING

Paoli, Pennsylvania, 19301, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
RECRUITING

Savannah, Georgia, 31405, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care
RECRUITING

Hinesville, Georgia, 31313, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care
RECRUITING

Jesup, Georgia, 31545, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: SJC Bluffton Campus
RECRUITING

Bluffton, South Carolina, 29910, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: South Carolina Cancer Specialists
RECRUITING

Hilton Head Island, South Carolina, 29926, United States
Lewistown Hospital
RECRUITING

Lewistown, Pennsylvania, 17044, United States
Lowell General Hosptial
RECRUITING

Lowell, Massachusetts, 01854, United States
Marshfield Medical Center
RECRUITING

Marshfield, Wisconsin, 54449, United States
Mercy Clinic Cancer and Hematology
RECRUITING

Rolla, Missouri, 65401, United States
Mercy Clinic East Communities
RECRUITING

St Louis, Missouri, 63128, United States
Mercy Clinic East Communities
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Clinic Fort Smith Communities
RECRUITING

Fort Smith, Arkansas, 72903, United States
Mercy Clinic Joplin, LLC
RECRUITING

Joplin, Missouri, 64804, United States
Mercy Clinic Oklahoma Communities, Inc.
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Mercy Clinic Springfield Communities
RECRUITING

Springfield, Missouri, 65804, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Research
RECRUITING

Fort Smith, Arkansas, 72903, United States
Mercyhealth Hospital and Cancer Center - Janesville
RECRUITING

Janesville, Wisconsin, 53548, United States
Metro MN
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States
Miami Valley Hospital North
RECRUITING

Englewood, Ohio, 45415, United States
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States
Minnesota Oncology - Burnsville
RECRUITING

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury
RECRUITING

Woodbury, Minnesota, 55125, United States
Mississippi Baptist Medical Center
RECRUITING

Jackson, Mississippi, 39202, United States
Montefiore
RECRUITING

New York, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
Monticello Cancer Center
RECRUITING

Monticello, Minnesota, 55362, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
New Ulm Medical Center
RECRUITING

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center
RECRUITING

Robbinsdale, Minnesota, 55422, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
ProHealth
RECRUITING

Waukesha, Wisconsin, 53022, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital
RECRUITING

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center
RECRUITING

Waconia, Minnesota, 55387, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Satellite of Bayhealth Sussex
RECRUITING

Milford, Delaware, 19901, United States
Sibley Johns Hopkins University
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States
Stanford Cancer Center Emeryville
RECRUITING

Emeryville, California, 94608, United States
Stanford Cancer Center South Bay
RECRUITING

San Jose, California, 95124, United States
Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States
The Cancer Institute at St. Francis Hospital
RECRUITING

East Hills, New York, 11548, United States
The Valley Hospital - Luckow Pavilion
RECRUITING

Paramus, New Jersey, 07652, United States
ThedaCare Cancer Care - Berlin
RECRUITING

Berlin, Wisconsin, 54923, United States
ThedaCare Cancer Care - New London
RECRUITING

New London, Wisconsin, 54961, United States
ThedaCare Cancer Care - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
ThedaCare Cancer Care - Shawano
RECRUITING

Shawano, Wisconsin, 54166, United States
ThedaCare Cancer Care - Waupaca
RECRUITING

Waupaca, Wisconsin, 54981, United States
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States
ThedaCare Regional Medical Center - Appleton
RECRUITING

Appleton, Wisconsin, 54911, United States
ThedaCare Regional Medical Center - Neenah
RECRUITING

Neenah, Wisconsin, 54956, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
Tufts Medical Center Cancer Center Stoneham
RECRUITING

Stoneham, Massachusetts, 02180, United States
UNC Pardee Cancer Center
RECRUITING

Hendersonville, North Carolina, 28791, United States
UT Southwest
RECRUITING

Dallas, Texas, 75235, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Wisconsin Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53715, United States
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic-Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States
Virtua Samson Cancer Center
RECRUITING

Moorestown, New Jersey, 08057, United States
Virtua Voorhees
RECRUITING

Voorhees Township, New Jersey, 08043, United States

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