New oral cocktail aims to tame resistant childhood cancer
NCT ID NCT00093353
First seen May 12, 2026 · Last updated May 14, 2026 · Updated 1 time
Summary
This early-stage trial tested a combination of two chemotherapy drugs (irinotecan and temozolomide) plus an antibiotic (cefixime) in 30 children whose high-risk neuroblastoma had come back or not responded to treatment. The main goal was to find the safest dose of oral irinotecan and see if cefixime could prevent a common side effect—diarrhea. While the study focused on safety and dosing, it offers a potential new option for children with this aggressive cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
Atlanta, Georgia, 30322, United States
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Children's Hospital Boston
Boston, Massachusetts, 02115, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027-0700, United States
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Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Memorial Hospital - Chicago
Chicago, Illinois, 60614, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039, United States
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Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289, United States
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Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital
Houston, Texas, 77030-2399, United States
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UCSF Comprehensive Cancer Center
San Francisco, California, 94143, United States
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University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0718, United States
Conditions
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