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Oxygen flow settings after breathing tube removal put to the test

NCT ID NCT07007715

Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial tests four different methods for setting the flow rate of a high-flow nasal cannula (a device that delivers warm, moist oxygen) after a breathing tube is removed. The goal is to find which approach best prevents the need for additional breathing support or re-intubation. About 480 adults who are ready to have their breathing tube removed will be randomly assigned to one of four flow-setting strategies: a fixed low flow, a fixed high flow, or one of two methods that tailor the flow to the patient's breathing or oxygen levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-flow nasal cannula oxygen therapy with different flow-setting strategies
What this could lead to
If successful, this could establish a standard, evidence-based method for setting oxygen flow after breathing-tube removal, potentially reducing the need for further breathing support.
What could go wrong
This is a single-center trial testing different flow-setting strategies, not a new drug or device. The best approach may still fail to improve outcomes, and results may not apply to all hospitals or patient types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 480 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Intubated and receiving mechanical ventilation for more than 24 hours * Ready for planned extubation after passing a spontaneous breathing trial * PaO2/FiO2 \<350 mmHg on the day of extubation Exclusion Criteria: * Age \<18 years * On do-not-reintubate code * Pregnant women * Having tracheostomies * Infeasibility of using HFNC * Planning to use preventive NIV after extubation by the primary care team * Life expectancy less than one month

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extubation readiness Respiratory failure with hypoxia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taiwan

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