New hope for lung cancer patients: experimental drug aims to extend life after other treatments fail

NCT ID NCT05671510

Ongoing Disease control Sponsor: OncoC4, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tests a new drug called gotistobart (ONC-392) against standard chemotherapy (docetaxel) in people with advanced non-small cell lung cancer that worsened after prior immunotherapy. About 630 adults will receive either the new drug or chemotherapy every 3 weeks for up to a year. The main goal is to see if the new drug helps patients live longer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

AOU Policlinico Giaccone, Università di Palermo - 2309

Palermo, 90129, Italy
AZ Maria Middelares - 2104

Ghent, 9000, Belgium
Adana Sehir Hastanesi - 2602

Adana, Turkey (Türkiye)
AdventHealth Cancer Institute - 1105

Orlando, Florida, 32804, United States
Affiliated Hospital of Hebei University - 3214

Zhengzhou, Hebei, 71000, China
Akdeniz University Medical Hospital - 2606

Antalya, Turkey (Türkiye)
Anhui Medical University - The Second Hospital - 3222

Hefei, Anhui, 231200, China
Ankara Bilkent Sehir Hastanesi - 2610

Ankara, 06800, Turkey (Türkiye)
Antoni van Leeuwenhoek - 2703

Amsterdam, 1066 CV, Netherlands
Asan Medical Centre - 3103

Seoul, 05505, South Korea
Asklepios Fachkliniken Muenchen-Gauting - 2203

Muenchen-Gauting, 82131, Germany
Astera Cancer Care - 1128

East Brunswick, New Jersey, 08816, United States
Azienda Ospedaliera Universitaria "Federico II" - 2304

Naples, 80131, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - 2310

Bergamo, 24126, Italy
BC Cancer Centre - Kelowna - 1203

Kelowna, British Columbia, Canada
Bankstown Hospital - 3305

Bankstown, New South Wales, 2200, Australia
Barts Health NHS Trust (St. Bartholomew's Hospital) - 2803

London, England, EC1A 7BE, United Kingdom
Baskent University Adana - 2601

Adana, Turkey (Türkiye)
Bass Medical Group - 1155

Walnut Creek, California, 94598, United States
Beijing Cancer Hospital - 3205

Beijing, Beijing Municipality, China
C. H. R. de la Citadelle - 2103

Liège, 4000, Belgium
Cambridge University Hospitals - 2804

Cambridge, England, CB2 0QQ, United Kingdom
Cancer Care Associates of York, Inc. - 1113

York, Pennsylvania, 17403, United States
Cancer Hospital, Chinese Academy of Medical Sciences - 3211

Beijing, Beijing Municipality, China
Cancer Research SA - 3303

Adelaide, South Australia, 5000, Australia
Chengdu Seventh People's Hospital - 3229

Chengdu, Sichuan, 610041, China
China-Japan Friendship Hospital - 3236

Beijing, 100029, China
Chongqing University Cancer Hospital - 3213

Chongqing, Sichuan, China
Chungbuk National University Hospital - 3101

Cheongju-si, 28644, South Korea
Clinica Oncologica Ospedali Riuniti Ancona - 2311

Ancona, 60126, Italy
Cotton O'Neil Clinical Research Center - 1151

Topeka, Kansas, 66606, United States
D&H Cancer Research Center LLC - 1153

Margate, Florida, 33063, United States
Deaconess Chancellor Center for Oncology - 1131

Newburgh, Indiana, 47630, United States
Donald Guthrie Foundation - 1135

Sayre, Pennsylvania, 18840, United States
Dongguan People's Hospital - 3206

Dongguan, Guangdong, China
Duke University Medical Center - 1158

Durham, North Carolina, 27710, United States
ETZ Elisabeth - 2704

Tilburg, 5022 GC, Netherlands
Edinburgh Cancer Centre - 2809

Edinburgh, Scotland, EH54 6PP, United Kingdom
Emad Ibrahim MD Inc. - 1147

Redlands, California, 92373, United States
Florida Cancer Specialists -East - 1124

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists -North - 1125

The Villages, Florida, 32159, United States
Florida Cancer Specialists -South - 1126

Sarasota, Florida, 34232, United States
Fondazione IRCCS Instituto Tumori Di Milano - 2305

Milan, 20133, Italy
Fort Wayne Medical Oncology - 1133

Fort Wayne, Indiana, 46805, United States
Fujian Medical University Union Hospital - 3225

Fuzhou, Fujian, China
Fundacion Instituto Valenciano De Oncologia (IVO) - 2402

Valencia, 56009, Spain
Genesis Cancer and Blood Institute - 1123

Russellville, Arkansas, 72801, United States
Guangdong Provincial People's Hospital - 3201

Guangzhou, Guangdong, 510105, China
Göztepe Prof Dr. Suleyman Yalcin City Hospital - 2605

Istanbul, Turkey (Türkiye)
Hacettepe Universitesi - 2609

Ankara, 06230, Turkey (Türkiye)
Hainan General Hospital - 3202

Haikou, Hainan, China
Henan Cancer Hospital - 3226

Zhengzhou, Henan, 450008, China
Hospital General Universitario Gregorio Marañon - 2404

Madrid, 28007, Spain
Hospital General Universitario de Elche - 2401

Elche, 03203, Spain
Hospital General Universitario de Valencia - 2406

Valencia, 46014, Spain
Hospital Regional Universitario de Malaga - 2403

Málaga, 29010, Spain
Hospital Universitario Lucus Augusti - 2405

Lugo, 27003, Spain
Hubei Cancer Hospital - 3237

Wuhan, 430079, China
Humanitas Istituto Clinico Catanese - 2312

Catania, 95045, Italy
Hunan Cancer Hospital - 3209

Changsha, Hunan, China
IRCCS Istituto Tumori Giovanni Paolo II - 2306

Bari, 70124, Italy
Istanbul Bakirkoy Sadi Konuk - 2604

Istanbul, Turkey (Türkiye)
Istanbul Üniversitesi Onkoloji Enstitüsü - 2613

Fatih, 34093, Turkey (Türkiye)
Izmir Ekonomi Universitesi Medical Point Hastanesi - 2607

Izmir, Turkey (Türkiye)
Jefferson City Medical Group - 1145

Jefferson City, Missouri, 65109, United States
Jessa Ziekenhuis (Jessa Hospital) - Campus Salvator - 2102

Hasselt, 3500, Belgium
Jinan Central Hospital - 3230

Jinan, Shandong, 250013, China
Keimyung University Dongsan Hospital - 3102

Daegu, 42601, South Korea
Kliniken Essen-Mitte - 2206

Essen, 45136, Germany
Klinikum Esslingen GmbH - 2201

Esslingen am Neckar, 73730, Germany
Klinikverbund Allgaü - Klinikum Kempten - 2205

Immenstädt, 87509, Germany
Koc Universitesi - 2611

Istanbul, 34010, Turkey (Türkiye)
Korea University Guro Hospital - 3106

Seoul, 08308, South Korea
Lungenfachklinik Immenhausen - 2202

Immenhausen, 34376, Germany
Mater - 3301

Newstead, Queensland, 4006, Australia
Medipol University Medical Faculty Hospital - 2603

Istanbul, Turkey (Türkiye)
Miami Valley Hospital - 1115

Centerville, Ohio, 45459, United States
MidAmerica Cancer Care - 1163

Kansas City, Missouri, 64132, United States
NEXT Oncology - Virginia - 1129

Fairfax, Virginia, 22031, United States
Nanjing Medical University (NMU) - Nanjing First Hospital - 3239

Jiangse, 21006, China
National Cancer Center - 3107

Goyang-si, 10408, South Korea
Norton Cancer Institute - 1108

Louisville, Kentucky, 40202, United States
Nuvance Health - 1118

Norwalk, Connecticut, 06850, United States
Ocala Oncology Center PL - 1102

Ocala, Florida, 34474, United States
Oklahoma Cancer Specialists and Research Institute - 1154

Tulsa, Oklahoma, 74146, United States
Oncology Associates of Oregon - 1138

Eugene, Oregon, 97401, United States
Oncology Consultants, P.A. - 1120

Houston, Texas, 77024, United States
Oncology and Hematology of South Texas - 1165

Laredo, Texas, 78041, United States
Orchard Healthcare Research, Inc. - 1116

Skokie, Illinois, 60077, United States
Orlando Health - 1130

Orlando, Florida, 32806, United States
Ospedale San Gerardo di Monza - 2302

Monza, 20900, Italy
Ospedale San Raffaele - 2307

Milan, 20132, Italy
Renmin Hospital of Wuhan University - 3216

Wuhan, Hubei, China
Rijnstate Ziekenhuis - 2701

Arnhem, 6815, Netherlands
Royal Devon University Healthcare NHS - 2808

Exeter, England, EX25DW, United Kingdom
Sarah Cannon Research Institute - Tennessee Oncology at Nashville - 1119

Nashville, Tennessee, 37203, United States
Saskatchewan Cancer Agency - Regina - 1201

Regina, Saskatchewan, S4T 7T1, Canada
Saskatchewan Cancer Agency - Saskatoon Cancer Centre - 1202

Saskatoon, Saskatchewan, S7N 4H4, Canada
Severance Hospital, Yonsei University Health System - 3104

Seoul, 03722, South Korea
Shanxi Bethune Hospital - 3233

Taiyuan, Shanxi, 30032, China
Sichuan Cancer Hospital - 3227

Chengdu, Sichuan, 610041, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine - 3219

Hangzhou, Zhejiang, China
South Tees Hospitals - 2807

Middlesbrough, England, TS4 3BW, United Kingdom
Springfield Clinic - The Cancer Center - 1110

Springfield, Illinois, 62702, United States
St. Luke's University Health Network - 1179

Bethlehem, Pennsylvania, 18015, United States
Städt. Klinikum München GmbH - 2204

Bogenhausen, 81925, Germany
Texas Oncology - Baylor Charles A. Sammons Cancer Center (USOR) - 1140

Dallas, Texas, 75246, United States
Texas Oncology - Denison - 1139

Denison, Texas, 75020, United States
Texas Oncology - McAllen - 1132

McAllen, Texas, 78503, United States
Texas Oncology -San Antonio - 1122

San Antonio, Texas, 78240, United States
The Affiliated Tumor Hospital of Harbin Medical University - 3232

Harbin, Heilongjiang, 150040, China
The Catholic University of Korea, St Vincent's Hospital - 3105

Suwon, 16247, South Korea
The Christie NHS Foundation Trust - 2802

Manchester, London, M20 4BX, United Kingdom
The First Affiliated Hospital of Anhui Medical University - 3221

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Guangdong Pharmaceutical University - 3215

Guangzhou, Guangdong, China
The First Affiliated Hospital of Xi'an Jiaotong University - 3218

Xi’an, Shanxi, China
The First Affiliated Hospital of Xiamen University - 3210

Xiamen, Fujian, China
The First Affliated Hospital of Zhengzhou University - 3207

Zhengzhou, Henan, China
The Ohio State University James Cancer Center - 1104

Columbus, Ohio, 43210, United States
The Oncology Institute (TOI) Clinical Research - 1109

Cerritos, California, 90703, United States
The People's Hospital of Guangxi Zhuang Autonomous Region - 3228

Nanning, Guangxi, 530021, China
The Second Affiliated Hospital of Nanchang University - 3224

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital of Soochow University - 3217

Suzhou, Jiangsu, China
The Second Affiliated Hospital of Zhejiang University School of Medicine - 3220

Hangzhou, Zhejiang, China
Tianjin Medical University Cancer Institute and Hospital - 3208

Tianjin, Tianjin Municipality, China
Tongji University - Shanghai Oriental Hospital (Shanghai East Hospital) - 3240

Shanghai, 200120, China
Torbay and South Devon NHS Foundation Trust - 2805

Torquay, England, TQ2 7AA, United Kingdom
Trakya University Faculty of Medicine Edirne - 2608

Edirne, Turkey (Türkiye)
Tri County Hematology & Oncology Associates, Inc - 1156

Massillon, Ohio, 44646, United States
UC Davis Comprehensive Cancer Center - 1103

Sacramento, California, 95817, United States
Union Hospital Tongji Medical College - 3212

Wuhan, Hubei, China
Universita Campus Bio-medico Di Roma (UCBM) - Policlinico Universitario - 2303

Roma, 00128, Italy
Universita degli Studi di Perugia - Ospedale Santa Maria della Misericordia - 2308

Perugia, 06132, Italy
University College London Hospital - 2811

London, NW1 2PG, United Kingdom
University Hospital Birmingham (UHB) / Queen Elizabeth Hospital Birmingham - 2801

Birmingham, England, B15 2TG, United Kingdom
University Hospital Leicester - 2806

Leicester, England, LE1 5WW, United Kingdom
University of Cincinnati Cancer Center - 1107

Cincinnati, Ohio, 45219, United States
University of Kentucky - Markey Cancer Center - 1112

Lexington, Kentucky, 40536, United States
University of Tennessee Medical Center - 1146

Knoxville, Tennessee, 37920, United States
Virginia Cancer Institute - 1149

Henrico, Virginia, 23226, United States
Virginia Oncology Associates - 1136

Norfolk, Virginia, 23502, United States
Vitaz - Sint-niklaas Moerland - 2101

Sint-Niklaas, 9100, Belgium
Weifang Second People's Hospital - 3235

Shandong, 261041, China
West China Hospital, Sichuan University - 3238

Chengdu, 610041, China
West Virginia University Cancer Institute - 1172

Morgantown, West Virginia, 26505, United States
Western Health - Sunshine Hospital - 3307

St Albans, Victoria, 3021, Australia
XCancer/Dothan Hematology & Oncology - 1114

Dothan, Alabama, 36303, United States
Xiangya Hospital, Central South University - 3223

Changsha, Hunan, 410008, China
Xuzhou Medical University - The Affiliated Hospital - 3234

Xuzhou, Jiangsu, 221002, China
Yunnan Cancer Hospital - 3231

Kunming, Yunnan, 650118, China
Zhejiang Cancer Hospital - 3204

Hangzhou, Zhejiang, China
Zhujiang Hospital of Southern Medical University - 3203

Guangzhou, Guangdong, 510280, China

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