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Cancer-Killing virus shows promise in tough ovarian cancer trial

NCT ID NCT05281471

Recruiting now Disease control Sponsor: Genelux Corporation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This Phase 3 study tests whether a modified virus called Olvi-Vec, given with chemotherapy and bevacizumab, can help women with ovarian cancer that no longer responds to platinum drugs. About 186 participants will receive either the virus combination or standard chemotherapy. The goal is to see if the virus can make the cancer sensitive to platinum again and slow disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Olvi-Vec (a modified virus that targets and kills cancer cells), followed by platinum chemotherapy and bevacizumab
What this could lead to
If successful, this could offer a new treatment option for women with hard-to-treat ovarian cancer that has stopped responding to platinum-based chemotherapy.
What could go wrong
This is an early Phase 3 trial with only 186 participants, so results may not apply to all patients. The virus-based therapy may cause side effects or fail to improve outcomes compared to current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma ovarian clear cell cancer ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma vaccinia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOID OVARIAN CANCER FALLOPIAN TUBE CANCER HIGH GRADE SEROUS OVARIAN CANCER OVARIAN CLEAR CELL CARCINOMA PLATINUM-REFRACTORY OVARIAN CANCER PLATINUM-RESISTANT OVARIAN CANCER PRIMARY PERITONEAL CANCER

Contacts and locations

Locations

  • AHN West Penn Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • AdventHealth Cancer Institute

    RECRUITING

    Orlando, Florida, 32804, United States

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • Center of Hope

    RECRUITING

    Reno, Nevada, 89511, United States

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • East Carolina University

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Erlanger Health, Inc.

    RECRUITING

    Chattanooga, Tennessee, 37403, United States

  • Hoag Gynecologic Oncology

    RECRUITING

    Newport Beach, California, 92663, United States

  • Hollings Cancer Center

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Holy Cross Hospital

    RECRUITING

    Silver Spring, Maryland, 20910, United States

  • Indiana University Simon Comprehensive Cancer Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

  • Kettering Health

    RECRUITING

    Kettering, Ohio, 45429, United States

  • Levine Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Mercy Hospital St. Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

  • OhioHealth Research Institute

    RECRUITING

    Columbus, Ohio, 43214, United States

  • Oklahoma University Health Stephenson Cancer Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • ProMedica Flower Hospital

    RECRUITING

    Sylvania, Ohio, 43560, United States

  • Providence Sacred Heart Medical Center & Children's Hospital

    RECRUITING

    Spokane, Washington, 99204, United States

  • Sarasota Memorial Healthcare System

    RECRUITING

    Sarasota, Florida, 34239, United States

    Contact Email: •••••@•••••

  • Stony Brook Cancer Center

    RECRUITING

    Stony Brook, New York, 11794, United States

  • The University of South Alabama, Mitchell Cancer Institute

    RECRUITING

    Mobile, Alabama, 36604, United States

  • UC San Diego Health - Moores Cancer Center

    RECRUITING

    La Jolla, California, 92093, United States

  • UCI Health Chao Family Comprehensive Cancer Center

    RECRUITING

    Orange, California, 92868, United States

  • University of Arizona Cancer Center

    RECRUITING

    Tucson, Arizona, 85719, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Texas Science Center at Houston, McGovern Medical School

    RECRUITING

    Houston, Texas, 77030, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Women's Cancer Associates with Women's Care Florida

    RECRUITING

    St. Petersburg, Florida, 33713, United States

  • Women's Cancer Center of Nevada

    RECRUITING

    Las Vegas, Nevada, 89106, United States

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