New shot slashes hidden heart risk in landmark trial
NCT ID NCT04270760
First seen Apr 07, 2026 · Last updated May 14, 2026 · Updated 6 times
Summary
This study tested a new drug called olpasiran in 281 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. Participants received either the drug or a placebo as a shot. The main goal was to see if olpasiran could safely lower Lp(a) levels over several months. The trial has completed, and results show it effectively reduced this risk factor.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aarhus Universitetshospital
Aarhus N, 8200, Denmark
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Academisch Medisch Centrum
Amsterdam, 1105 AZ, Netherlands
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Asahi General Hospital
Asahi-shi, Chiba, 289-2511, Japan
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Asahikawa City Hospital
Asahikawa-shi, Hokkaido, 070-8610, Japan
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinique des Maladies Lipidiques de Quebec Incorporated
Québec, Quebec, G1V 4W2, Canada
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Columbia University Medical Center
New York, New York, 10032, United States
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Core Research Group Pty Ltd
Milton, Queensland, 4064, Australia
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Crossroads Clinical Research Inc
Mooresville, North Carolina, 28117, United States
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Dr Heart Pty Ltd
Woolloongabba, 4102, Australia
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Ecogene-21
Chicoutimi, Quebec, G7H 7K9, Canada
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Excel Medical Clinical Trials
Boca Raton, Florida, 33434, United States
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Haga Ziekenhuis
The Hague, 2545 AA, Netherlands
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Herlev Gentofte Hospital
Herlev, 2730, Denmark
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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Kanazawa Medical University Hospital
Kahoku-gun, Ishikawa-ken, 920-0293, Japan
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LMC Clinical Research Incorporated
Brampton, Ontario, L6S 0C6, Canada
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LMC Clinical Research Incorporated Thornhill
Concord, Ontario, L4K 4M2, Canada
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Linear Clinical Research Limited
Nedlands, Western Australia, 6009, Australia
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Mount Sinai Hospital
New York, New York, 10029, United States
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New York University
New York, New York, 10016, United States
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Piedmont Healthcare
Atlanta, Georgia, 30309, United States
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Protenium Clinical Research
Hurst, Texas, 76054, United States
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Regionshospitalet Viborg
Viborg, 8800, Denmark
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Research Institute of McGill University Health Center - Glen Site
Montreal, Quebec, H4A 3J1, Canada
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Rijnstate Ziekenhuis
Arnhem, 6815 AD, Netherlands
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Saitama Medical University Hospital
Iruma-gun, Saitama, 350-0495, Japan
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The Jikei University Kashiwa Hospital
Kashiwa-shi, Chiba, 277-8567, Japan
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Thjonustumidstod Rannsoknaverkefna
Kopavogur, 201, Iceland
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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VieCuri Medisch Centrum
Venlo, 5912 BL, Netherlands
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Westside Medical Associates of Los Angeles
Beverly Hills, California, 90211, United States
Conditions
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