New hope for lymphoma patients: drug duo shows promise in early trial

NCT ID NCT05267054

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 24 times

Summary

This study tested a new combination of drugs (ociperlimab plus tislelizumab or rituximab) in 53 adults with diffuse large B-cell lymphoma that had come back or not responded to prior treatment. The main goals were to check safety and find the best dose. Researchers also looked at whether the treatment shrank tumors. This is an early-phase trial, so results help guide future studies.

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Contacts and locations

Locations

  • Affiliated Zhongshan Hospital of Fudan University

    Shanghai, Shanghai Municipality, 200032, China

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100142, China

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050, China

  • Beijing Hospital

    Beijing, Beijing Municipality, 100730, China

  • Guangdong Provincial Peoples Hospital

    Guangzhou, Guangdong, 510080, China

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450000, China

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013, China

  • Jiangxi Province Cancer Hospital

    Nanchang, Jiangxi, 330029, China

  • Shandong Cancer Hospital

    Jinan, Shandong, 250117, China

  • Shengjing Hospital of China Medical University

    Shenyang, Liaoning, 110004, China

  • Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

    Chengdu, Sichuan, 610071, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016, China

  • Sun Yat Sen University Cancer Center

    Guangzhou, Guangdong, 510060, China

  • The First Affiliated Hospital of Nanchang University Branch Donghu

    Nanchang, Jiangxi, 330006, China

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, Tianjin Municipality, 300060, China

  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022, China

  • Zhujiang Hospital of Southern Medical University

    Guangzhou, Guangdong, 510000, China

Conditions

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