Could a liver drug shrink polyps in rare genetic disease?
NCT ID NCT05223036
First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 30 times
Summary
This study tests whether a daily pill called obeticholic acid (OCA) can safely reduce the number of polyps in the small bowel and colon in people with familial adenomatous polyposis (FAP), a rare inherited condition that greatly raises the risk of intestinal cancer. About 80 adults with FAP will receive either OCA or a placebo for a set period. The goal is to see if OCA, already approved for a liver disease, can help control polyp growth and lower cancer risk.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Puerto Rico
San Juan, 00936, Puerto Rico
Conditions
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