Lupus drug trial hopes to tame flares with targeted antibody
NCT ID NCT04963296
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 study tests whether obinutuzumab, an antibody drug given by IV, can better control active lupus compared to a placebo. About 303 adults with lupus who have high disease activity and specific antibodies are taking part. All participants continue their usual lupus medications while receiving either obinutuzumab or placebo infusions over several months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
obinutuzumab (a targeted antibody drug given by IV infusion)
What this could lead to
If it works, this could offer a new treatment option to better control lupus flares and reduce disease activity.
What could go wrong
This is an early-stage Phase 3 trial with 303 participants, so results may not apply to all lupus patients. The drug also carries infusion-related risks and may not outperform placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O. Universitaria Pisana
Pisa, Tuscany, 56126, Italy
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Addenbrooke'S Hospital
Cambridge, CB2 2QQ, United Kingdom
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Arthritis & Rheumatism
Aventura, Florida, 33180, United States
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Azienda Ospedaliero-Universitaria Di Ferrara Arcispedale Santanna
Cona (Ferrara), Veneto, 44124, Italy
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Centro Mineiro de Pesquisa - CMIP
Juiz de Fora, Minas Gerais, 36010-570, Brazil
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Centro Multidisciplinar de Estudos Clínicos - CEMEC*X*
São Bernardo do Campo, São Paulo, 09715-090, Brazil
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Centro de Estudos em Terapias Inovadoras ? CETI
Curtiba, Paraná, 80030-110, Brazil
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Centro de Investigacion Alberto Bazzoni S.A. de C.V.
Torreón, Coahuila, 27000, Mexico
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Centro de Investigaciones Médicas Tucuman
San Miguel, T4000AXL, Argentina
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Centro de Investigación de Tratamientos Innovadores de Sinaloa (CITI)
Culiacán, Sinaloa, 80000, Mexico
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Centro de Investigación y Tratamiento Reumatológico S.C.
Mexico City, Mexico CITY (federal District), 11850, Mexico
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Ch Pitie Salpetriere
Paris, 75651, France
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Chapel Allerton Hospital
Leeds, LS1 3EX, United Kingdom
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Clinica El Golf
San Isidro, L27 Lima, Peru
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Clinica San Antonio;Investigaciones Trujillo S.A.C.
Trujillo, 13008, Peru
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Clinical Research Institute of Michigan, LLC
Troy, Michigan, 48047, United States
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Clínica San Juan Bautista CSJB
Lima, 15431, Peru
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Columbia University Medical Center
New York, New York, 10032, United States
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DOM Centro de Reumatología
Buenos Aires, C1111AAJ, Argentina
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Dr Asokan Naidoo
Umhlanga, 4319, South Africa
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Emmed Research
Pretoria, 0002, South Africa
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FGBU ?Federal Medical and Research Center named after V.A.Almazov? Russian Ministry of Health
Saint Petersburg, Sankt-Peterburg, 197341, Russia
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Federal State Budgetary Scientific Institution Research Institute of Rheumatology V.A. Nasonova
Moscow, Moscow Oblast, 115522, Russia
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Great Lakes Center of Rheumatology
Lansing, Michigan, 48911, United States
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Guy's Hospital
London, SE1 9RT, United Kingdom
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Hogar Clínica San Juan de Dios
Arequipa, 04000, Peru
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, 64460, Mexico
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital das Clinicas - FMUSP Ribeirao Preto
Ribeirão Preto, São Paulo, 14051-140, Brazil
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Hospital das Clinicas - UFMG
Belo Horizonte, Minas Gerais, 30130-100, Brazil
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IRCCS S. Raffaele
Milan, Lombardy, 20132, Italy
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Instituto de Ginecología y Reproducción
Lima, Peru
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Joint & Muscle Research Institute
Charlotte, North Carolina, 28204, United States
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MICS Centrum Medyczne Warszawa
Warsaw, 00-874, Poland
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Manchester Royal Infirmary
Manchester, M13 9WL, United Kingdom
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Medyczne Centrum Hetmanska
Poznan, 60-218, Poland
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Middlemore Hospital
Auckland, 2025, New Zealand
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Northwell Health Division of Rheumatology
Great Neck, New York, 11021, United States
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Organizacion Medica de Investigacion
Buenos Aires, C1015ABO, Argentina
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Ortopedyczno Rehab Szpital Klinic im Wiktora Degi UM
Poznan, 61-545, Poland
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Panorama Medical Center
Cape Town, 7500, South Africa
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Paramount Medical Research & Consulting, LLC
Middleburg Heights, Ohio, 44130, United States
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Pinnacle Research Group
Anniston, Alabama, 36207, United States
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Policlinico Universitario Agostino Gemelli
Rome, Lazio, 00168, Italy
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Precision Comprehensive Clinical Research Solutions
Colleyville, Texas, 76034, United States
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Prolato Clinical Research Center
Houston, Texas, 77054, United States
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Providence Medical Foundation
Fullerton, California, 92835, United States
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Prywatna Praktyka Lekarska
Poznan, 61-397, Poland
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REUMATOP Grzegorz Rozumek, Karin Pistorius Spó?ka Jawna
Wroc?aw, 52-210, Poland
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Republican clinical hospital named after G.G. Kuvatov
Ufa, Bashkortostan Republic, 450005, Russia
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Revmatologicky Ustav
Prague, 128 50, Czechia
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Rheuma Medicus Zaklad Opieki Zdrowotnej
Warsaw, 02-118, Poland
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Royal Free Hospital
London, NW3 2QG, United Kingdom
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Santa Casa de Misericordia
Belo Horizonte, Minas Gerais, 30150-221, Brazil
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Ser Servicos Especializados Em Reumatologia
Salvador, Estado de Bahia, 40150-150, Brazil
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Szpital Uniwersytecki
Bydgoszcz, 85-168, Poland
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Texas Arthritis Center
El Paso, Texas, 79902, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43212, United States
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Uni Di Padova
Padova, Veneto, 35128, Italy
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Unidad de Reumatologia Rehabilitacion Integral
Mexicali, Estado de Baja California, 21100, Mexico
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Unity Health - White County Medical Center- Rheumatology
Searcy, Arkansas, 72143, United States
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Wellington Hospital
Wellington, 0621, New Zealand
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Winelands Medical Research
Cape Town, 7600, South Africa