Could a bile acid blocker stop esophageal cancer before it starts?
NCT ID NCT04939051
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 30 times
Summary
This study tests whether obeticholic acid can prevent cancer in people with Barrett's esophagus, a condition that raises the risk of esophageal cancer. The drug works by reducing damage from bile acids that flow back into the esophagus. About 30 adults with Barrett's esophagus will take the drug or a placebo to see if it lowers certain cell changes linked to cancer risk.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Case Western Reserve University
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seidman Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospitals Cleveland Medical Center
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan Rogel Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Conditions
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