Could a simple supplement ease sickle cell symptoms?

NCT ID NCT05791591

Completed Disease control Sponsor: LGD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a nutraceutical supplement called NUV001 in 168 adults with sickle cell disease. Participants took either an immediate-release or gastro-resistant version of NUV001, or a placebo, daily for 90 days. The main goal was to check safety and tolerability, with early looks at blood markers and patient-reported outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NUV001 (a nutraceutical supplement)
What this could lead to: If it works, this could point toward a safe, daily supplement to help manage sickle cell disease symptoms alongside standard care.
What could go wrong: This is a small, early pilot study focused on safety, not proof of effectiveness. The supplement may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE

Contacts and locations

Locations

Aman Hospital and Research Center

Vadodara, Gujarat, Vadodara-390021, India
Arihant Multispeciality Hospital

Nagpur, India
Index Medical College

Indore, India
Kingsway Hospital

Nagpur, Maharashtra, Nagpur-440001, India
NRSMC Hospital

Kolkata, India
Sai Krupa Hospital & Research Centre

Ahmedabad, India
Shalinitai Meghe Hospital & Research Centre

Nagpur, India
Shivam Hospital

Ahmedabad, 380008, India
Thalassemia & Sickle Cell Society

Hyderabad, India

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