New hope for Hard-to-Treat breast cancer: targeted combo enters final testing
NCT ID NCT07393321
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether adding the experimental drug NTQ1062 to standard hormone therapy (fulvestrant) can slow or stop the growth of advanced HR+/HER2- breast cancer in people whose cancer has returned or worsened after hormone therapy. The study includes 210 adults with specific genetic changes (PIK3CA/AKT1/PTEN). Participants will receive either NTQ1062 plus fulvestrant or a placebo plus fulvestrant, and researchers will track how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NTQ1062 (an AKT inhibitor) combined with fulvestrant
What this could lead to
If successful, this combination could offer a new treatment option for people with a specific genetic subtype of advanced breast cancer that has stopped responding to hormone therapy.
What could go wrong
This is an early-stage Phase 3 trial with only 210 participants, so results may not apply to everyone. The drug may not improve survival or could cause side effects like those seen with other AKT inhibitors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.