Can Anti-Inflammatories after spine surgery reduce opioid use without harming healing?
NCT ID NCT07743606
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This trial compares two pain management approaches after lumbar spine fusion surgery: standard pain medication alone versus standard care plus a short course of NSAIDs (ketorolac in the hospital and naproxen for a week after discharge). The main question is whether adding NSAIDs affects bone healing, specifically the risk of needing another surgery due to failed fusion. The study also tracks pain medication use, recovery, complications, and patient-reported outcomes to see if NSAIDs can safely reduce opioid reliance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ketorolac and naproxen (NSAIDs)
- What this could lead to
- If NSAIDs prove safe, they could become a standard part of pain management after spine fusion, potentially reducing opioid use.
- What could go wrong
- The trial is still in progress, and results may show that NSAIDs increase the risk of failed bone healing, leading to more surgeries.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, 19107, United States
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