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Can a blood pressure drug make kidney stone surgery safer?

NCT ID NCT07786844

Disease control Sponsor: Geriatric Hospital of Nanjing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial investigates whether adding norepinephrine to the irrigation fluid used during a type of kidney stone surgery can reduce bleeding and improve visibility for the surgeon. The study will enroll adults with kidney or upper ureteral stones who are undergoing a procedure using a single-use flexible ureteroscope with a negative pressure sheath. Researchers will test different concentrations of norepinephrine to find the safest and most effective dose for controlling bleeding during the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine irrigation fluid
What this could lead to
If effective, this approach could reduce bleeding during kidney stone surgery, improving visibility and safety, and potentially leading to better surgical outcomes and faster recovery.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not be conclusive. Norepinephrine can affect blood pressure and heart rate, and the optimal dose is still being determined.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 55 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age 18-75 years of either sex. * Clinically and radiologically confirmed renal or upper-ureteral stone with operative indication for super flexible ureteroscopic lithotripsy combined with negative pressure ultrasound lithotripsy (su-fURS + NPUAS). * Subjects with definite surgical indication for upper urinary tract stones, tolerate general anesthesia, and agree to receive the targeted operative procedure. Exclusion Criteria * Diagnosis of non-upper urinary tract stones. * Intolerance to flexible ureteroscopic surgery. * Poorly-controlled hypertension with blood pressure greater than 160/100 mmHg. * History of coronary artery disease.

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Conditions

The condition(s) this trial relates to.

urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lithotripsy Urolithiasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Geriatric Hospital of Nanjing Medical University

    RECRUITING

    Nanjing, Jiangsu, 210009, China

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