Tailoring blood pressure drugs by body weight could prevent dangerous drops during c-sections
NCT ID NCT07706426
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This study looks at whether a woman's body mass index (BMI) changes the amount of norepinephrine needed to prevent low blood pressure after spinal anesthesia for a C-section. Researchers will give different doses of norepinephrine to pregnant women with various BMIs and monitor how many develop low blood pressure. The goal is to find the safest and most effective dose for each body type.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- norepinephrine infusion at doses of 0.025, 0.05, 0.075, and 0.1 micrograms per kilogram per minute
- What this could lead to
- If successful, this could help doctors tailor norepinephrine doses to a woman's body size, reducing dangerous drops in blood pressure during C-sections.
- What could go wrong
- This is a small, early-phase study with only 80 participants, so results may not apply to all women. Norepinephrine can cause high blood pressure or slow heart rate as side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jul 2026
An estimate. Start dates often move.
- Expected to finish
-
Apr 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 40 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * A normal singleton pregnancy with a gestational age of ≥ 37 weeks. 18-40 years old pregnant women scheduled for elective C/S under spinal anesthesia. Exclusion Criteria: * Any absolute contraindication to spinal block, Neurological or cardiac disorder, Basal systolic blood pressure above 140 mmHg or below 100 mmHg, Peripartum bleeding or emergent situations both for fetus and mother, Those who refused to participate in the study were excluded Known fetal abnormality, intrauterine growth restriction, Obstetric complication (ruptured membranes, placenta previa, placental abruption),
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Post spinal anaesthesia hypotension are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Ain Shams
Cairo, Abbasia, 00202, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.