New kidney scan measure could sharpen blockage detection
NCT ID NCT07811388
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers at Assiut University are comparing a newer kidney scan measure called Normalized Residual Activity (NORA) with standard measures from 99mTc-DTPA diuretic renography. The study enrolls 57 children and adults referred for suspected urinary tract obstruction. All participants receive the standard scan with a radioactive tracer and a diuretic. The goal is to see whether NORA better distinguishes true blockage from non-obstructive widening of the urinary tract.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 99mTc-DTPA, a radioactive tracer used in kidney imaging, plus furosemide, a diuretic
- What this could lead to
- If NORA proves more accurate, doctors could rely on it to tell true kidney blockage from harmless widening, helping patients avoid unnecessary surgery or get needed treatment sooner.
- What could go wrong
- This is a small single-center study of 57 people, so its findings may not hold up in larger or more varied groups. The reference standard itself depends on surgery or long follow-up, which can be imperfect.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 57 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Pediatric or adult patients referred for 99mTc-DTPA diuretic renography because of suspected urinary tract obstruction.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients fulfilling all of the following criteria will be eligible for inclusion: 1. Pediatric or adult patients referred for 99mTc-DTPA diuretic renography because of suspected urinary tract obstruction. 2. Availability of a clinical reference standard (e.g., confirmation of obstruction via surgical findings/pyeloplasty, or proven non-obstruction via stable long-term clinical and radiological follow-up of at least 6-12 months). Exclusion Criteria: Patients meeting any of the following criteria will be excluded: 1. Patients with severe renal impairment. 2. Patients with renal congenital anomalies e.g. horseshoe kidneys 3. Technical failure during the scan, including severe patient motion artifacts or failure to properly administer the diuretic
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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