Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a new filler smooth smile lines as well as the leading one?

NCT ID NCT07794878

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This study tests whether NOA LIFT, a hyaluronic acid filler, safely corrects moderate to severe nasolabial folds (smile lines) compared to JUVÉDERM VOLIFT with lidocaine. About 288 adults with similar folds on both sides of the nose will receive injections of one filler or the other. Researchers will check improvement using a standard severity scale and track side effects over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NOA LIFT, a hyaluronic acid-based dermal filler injected into the deep dermis
What this could lead to
If it works, NOA LIFT could offer a new option for smoothing moderate to severe nasolabial folds, with effects lasting up to a year.
What could go wrong
This is a Phase 3 trial, so earlier data may not predict real-world results. Risks include injection-site reactions, bruising, or uneven correction, and the filler may not match JUVÉDERM's effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 288 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Moderate (2) or Severe (3) on the 5-point Nasolabial Fold Severity Scale (NLFSS) for each nasolabial fold (NLF) on evaluator live assessment (both sides must qualify and have the same score) Exclusion Criteria: * Current cutaneous or mucosal inflammatory or infectious processes, abscess, unhealed wound, or cancerous or precancerous lesion in the treatment area(s). * Current enrollment in an investigational drug or device study or participation in such a study within 30 days before enrollment.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Nasolabial folds are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nasolabial folds

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nanjing Drum Tower Hospital /ID# 267555

    RECRUITING

    Nanjing, Jiangsu, 210008, China

  • Peking Union Medical College Hospital (West) - Xidan Campus /ID# 267457

    RECRUITING

    Beijing, Beijing Municipality, 100032, China

  • Peking University Shenzhen Hospital /ID# 268255

    RECRUITING

    Shenzhen, Guangdong, 518036, China

  • Xianyang Hospital of Yanan University /ID# 267936

    RECRUITING

    Xianyang, Shaanxi, 712000, China

  • Zhongda Hospital Of Southeast University /ID# 276571

    RECRUITING

    Nanjing, Jiangsu, 210009, China

  • Zhujiang Hospital /ID# 276566

    RECRUITING

    Guangzhou, Guangdong, 510280, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.