New filler aims to outlast current options for deep smile lines
NCT ID NCT06984835
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study compares two injectable fillers for nasolabial folds (the lines from nose to mouth). One side of the face gets the experimental filler ELLANSÉ®-S, the other gets the standard filler Radiesse®. About 126 adults with moderate to severe lines will be followed for up to 24 months to see which side holds up better and how safe each is.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ELLANSÉ®-S, a dermal filler made of polycaprolactone and carboxymethylcellulose gel, injected into nasolabial folds
- What this could lead to
- If it works, this could offer a longer-lasting option for smoothing deep smile lines.
- What could go wrong
- This is a mid-sized trial comparing two fillers, so results may not apply to all skin types or guarantee superiority. Risks include swelling, bruising, or uneven results.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Dermatology of Michigan
Warren, Michigan, 48088, United States
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Callender Center for Clinical Research
Glenn Dale, Maryland, 20769, United States
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Clinical Testing of Beverly Hills
Encino, California, 91436, United States
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DMR Research, PLLC
Westport, Connecticut, 06880, United States
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Investigate MD
Scottsdale, Arizona, 86260, United States
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Skin Research Institute LLC
Miami, Florida, 33146, United States
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Skincare Physicians
Chestnut Hill, Massachusetts, 02467, United States
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