Immune booster: donor NK cells aim to stop leukemia return after transplant
NCT ID NCT07256210
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This clinical trial tests whether infusions of donor natural killer (NK) cells, given before and after a stem cell transplant, can safely prevent leukemia from coming back in children and young adults with hard-to-treat acute leukemia. The study enrolls 15 patients aged 0 to 25 with chemorefractory or minimal residual disease positive leukemia. Researchers will monitor side effects and the maximum tolerated dose, as well as how well the treatment clears leukemia from the bone marrow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Donor-derived natural killer (NK) cells
- What this could lead to
- If successful, this approach could reduce the risk of leukemia returning after a stem cell transplant, offering a better chance of long-term remission for patients with difficult-to-treat acute leukemia.
- What could go wrong
- This is a small, early-phase trial with only 15 participants, so results may not apply broadly. There is a risk of serious side effects like graft-versus-host disease or infusion reactions, and the treatment may not prevent relapse.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and Immunology
RECRUITINGMoscow, 117997, Russia
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