New drug combo shows promise against rare skin cancer

NCT ID NCT03071406

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This study tests whether adding targeted radiation to a two-drug immunotherapy combination works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults with stage IV or recurrent disease will receive either nivolumab plus ipilimumab, or the same drugs plus stereotactic body radiation therapy. The goal is to see which approach shrinks tumors more effectively and keeps the cancer from growing.

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Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

Conditions

Explore the condition pages connected to this study.