Immunotherapy duo shows promise against brain metastases in melanoma

NCT ID NCT02374242

First seen Jan 05, 2026 · Last updated Apr 28, 2026 · Updated 13 times

Summary

This study tests whether the immunotherapy drug nivolumab, alone or combined with ipilimumab, can shrink melanoma tumors that have spread to the brain. About 76 adults with stage IV melanoma and at least one brain metastasis will receive one of the two treatments. The main goal is to see how many patients have their brain tumors shrink or disappear.

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Contacts and locations

Locations

  • Melanoma Institute Australia

    Wollstonecraft, New South Wales, 2065, Australia

  • Peter MacCallum Cancer Centre

    East Melbourne, Victoria, 3002, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

Conditions

Explore the condition pages connected to this study.