New drug duo shows promise for tough colorectal cancer

NCT ID NCT03983993

Ongoing Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial is testing whether combining two drugs—niraparib and panitumumab—can help people with advanced colorectal cancer that has spread. The study includes 26 patients whose cancer has not responded to at least one prior treatment. The goal is to see if the combination can shrink tumors or slow disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: niraparib and panitumumab
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced colorectal cancer that has not responded to other therapies.
What could go wrong: This is a small, early-phase trial with only 26 participants. The drugs may not work as hoped, and side effects could be significant. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MICROSATELLITE STABLE COLORECTAL CARCINOMA METASTATIC MICROSATELLITE STABLE COLORECTAL CARCINOMA MICROSATELLITE STABLE MSI-H COLORECTAL CANCER RAS WILD TYPE STAGE IV COLORECTAL CANCER AJCC V8

Contacts and locations

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Locations

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

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