New combo therapy aims to keep ovarian cancer at bay longer

NCT ID NCT05009082

Recruiting now Disease control Sponsor: AGO Study Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This Phase 3 trial is testing whether adding bevacizumab to niraparib after standard chemotherapy helps women with newly diagnosed advanced ovarian cancer stay cancer-free longer. About 970 participants will receive either niraparib alone or niraparib plus bevacizumab as maintenance therapy. The study compares how long the cancer stays under control and monitors side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Niraparib and bevacizumab
What this could lead to: If successful, this combination could extend the time women with advanced ovarian cancer live without their disease worsening, offering a new standard treatment option.
What could go wrong: This is a large Phase 3 trial, but results may not apply to all ovarian cancer types. Adding bevacizumab also increases side effects like high blood pressure and bleeding risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma peritoneum cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FALLOPIAN TUBE CANCER OVARIAN CANCER PERITONEAL CANCER

Contacts and locations

Locations

Albertinen Krankenhaus
RECRUITING

Hamburg, Germany
Florence-Nightingale-Krankenhaus Düsseldorf
NOT_YET_RECRUITING

Düsseldorf, Germany
Gyn.-onkolog. Gemeinschaftspraxis Hildesheim
RECRUITING

Hildesheim, Germany
Gynäkologisch-Onkologische Praxis am Pelikanplatz
RECRUITING

Hanover, Germany
Helios Klinikum Berlin-Buch
RECRUITING

Berlin, Germany
Hochtaunus-Kliniken
RECRUITING

Bad Homburg, Germany
KEM Essen | Evang. Kliniken Essen-Mitte gGmbH
RECRUITING

Essen, Germany
Klinikum Augsburg
RECRUITING

Augsburg, Germany
Klinikum Bremen Mitte
RECRUITING

Bremen, Germany
Klinikum Chemnitz
RECRUITING

Chemnitz, Germany
Klinikum Dortmund
RECRUITING

Dortmund, Germany
Klinikum Esslingen GmbH
RECRUITING

Esslingen am Neckar, Germany
Klinikum Frankfurt Höchst
RECRUITING

Frankfurt am Main, Germany
Klinikum Gütersloh
RECRUITING

Gütersloh, Germany
Klinikum Kassel
RECRUITING

Kassel, Germany
Klinikum Konstanz
NOT_YET_RECRUITING

Konstanz, Germany
Klinikum Ludwigsburg
RECRUITING

Ludwigsburg, Germany
Klinikum Mutterhaus
RECRUITING

Trier, Germany
Klinikum Neumarkt
RECRUITING

Neumarkt, Germany
Klinikum St. Marien Amberg
RECRUITING

Amberg, Germany
Klinikum Stuttgart
RECRUITING

Stuttgart, Germany
Klinikum Südstadt Rostock
RECRUITING

Rostock, Germany
Klinikum Traunstein
RECRUITING

Traunstein, Germany
Klinikum Worms
RECRUITING

Worms, Germany
Klinikum am Gesundbrunnen / SLK-Kliniken Heilbronn GmbH
RECRUITING

Heilbronn, Germany
Klinikum am Steinenberg
RECRUITING

Reutlingen, Germany
Klinikverbund Kempten-Oberallgäu gGmbH
NOT_YET_RECRUITING

Kempten, Germany
Krankenhaus Barmherzige Brüder
RECRUITING

Regensburg, Germany
LMU Klinikum München-Großhadern
RECRUITING

München, Germany
Leopoldina Krankenhaus Schweinfurt
RECRUITING

Schweinfurt, Germany
MVZ Nordhausen
RECRUITING

Nordhausen, Germany
Mammazentrum HH am Krankenhaus Jerusalem
RECRUITING

Hamburg, Germany
Mühlenkreiskliniken, Johannes Wesling Klinikum Minden
RECRUITING

Minden, Germany
Onkologische Schwerpunktpraxis Bielefeld
RECRUITING

Bielefeld, Germany
Ortenau Klinikum Offenburg-Kehl
RECRUITING

Offenburg, Germany
RoMed Klinikum Rosenheim
RECRUITING

Rosenheim, Germany
Rotkreuzklinikum München
RECRUITING

München, Germany
St. Elisabeth-Krankenhaus Köln-Hohenlind
RECRUITING

Cologne, Germany
St. Josefs-Hospital
RECRUITING

Wiesbaden, Germany
St. Vincenz Krankenhaus
RECRUITING

Limburg, Germany
St. Vincenz Krankenhaus GmbH
RECRUITING

Paderborn, Germany
Studienzentrum Onkologie Ravensburg
RECRUITING

Ravensburg, Germany
Städt. Klinikum Brandenburg
RECRUITING

Brandenburg an der Havel, Germany
Städtisches Klinikum Karlsruhe
RECRUITING

Karlsruhe, Germany
Thüringen-Kliniken "Georgius Agricola"
RECRUITING

Saalfeld, Germany
UKGM Gießen/Marburg Standort Marburg
RECRUITING

Marburg, Germany
UKSH Campus Lübeck
RECRUITING

Lübeck, Germany
Universitätsfrauenklinik Düsseldorf
RECRUITING

Düsseldorf, Germany
Universitätsklinik Ulm
RECRUITING

Ulm, Germany
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, Germany
Universitätsklinikum Essen
RECRUITING

Essen, Germany
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt, Germany
Universitätsklinikum Gießen
RECRUITING

Giessen, Germany
Universitätsklinikum Halle
RECRUITING

Halle, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Germany
Universitätsklinikum Mannheim GmbH
RECRUITING

Mannheim, Germany
Universitätsklinikum Münster
RECRUITING

Münster, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, Germany
Universitätsklnikum Heidelberg
RECRUITING

Heidelberg, Germany
Universitätsmedizin Mainz
RECRUITING

Mainz, Germany
Universtitätsklinikum Jena
RECRUITING

Jena, Germany
ViDia Christliche Kliniken Karlsruhe
RECRUITING

Karlsruhe, Germany
Zentrum für ambulante gynäkologische Onkologie am HELIOS Klinikum Krefeld
RECRUITING

Krefeld, Germany
g.SUND
RECRUITING

Stralsund, Germany

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