New hope for kids with rare Muscle-Weakening disease?

NCT ID NCT05265273

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a drug called nipocalimab in children aged 2 to 18 with generalized myasthenia gravis, a condition that causes muscle weakness. The goal is to see if the drug safely lowers certain immune proteins (IgG) and improves daily activities. About 12 children will receive the drug alongside their current standard care.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYASTHENIA GRAVIS

Contacts and locations

Locations

C.S. Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
Chiba University Hospital
COMPLETED

Chiba, 260 8677, Japan
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Childrens Hospital Los Angeles
COMPLETED

Los Angeles, California, 90027, United States
Childrens Hospital Of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19106, United States
Hyogo College of Medicine Hospital
RECRUITING

Nishinomiya-Shi, 663-8501, Japan
Leiden University Medical Center
RECRUITING

Leiden, 2333 ZA, Netherlands
Lucile Packard Children's Hospital Stanford
RECRUITING

Palo Alto, California, 94304, United States
Nagano Children's Hospital
RECRUITING

Azumino-shi, 399-8288, Japan
Penn State Milton S Hershey Medical Ctr
RECRUITING

Hershey, Pennsylvania, 17033, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Saitama Prefecture Children's Medical Center
RECRUITING

Saitama Shi, 330-8777, Japan
Tokyo Women's Medical University Hospital
RECRUITING

Shinjuku-ku, 162-8666, Japan
UCSF Benioff Children's Hospital
RECRUITING

San Francisco, California, 94158, United States
University of Kansas Medical Center
COMPLETED

Lawrence, Kansas, 66045, United States
University of Miyazaki Hospital
RECRUITING

Miyazaki, 889-1692, Japan
University of Pittsburgh Medical Center
TERMINATED

Pittsburgh, Pennsylvania, 15224, United States
University of South Florida Morsani Center for Advanced Healthcare
RECRUITING

Tampa, Florida, 33613, United States
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 211, Poland

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