Can a new drug quiet the 'Tangles' in Alzheimer's brains?

NCT ID NCT06372821

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jan 28, 2026 · Last updated May 10, 2026 · Updated 16 times

Summary

This study tests an experimental drug called NIO752 in 10 people with mild to moderate Alzheimer's. The drug is given via a spinal injection to try to reduce the brain's production of tau, a protein that forms harmful tangles and damages nerve cells. The main goal is to see if the drug safely lowers tau production, which could slow the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University College London Hospitals NHS Foundation Trust
RECRUITING

London, NW1 2PG, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

ALZHEIMER DISEASE AUTOSOMAL DOMINANT ALZHEIMER DISEASE DUE TO MUTATION OF AMYLOID PRECURSOR PROTEIN (DISORDER) AUTOSOMAL DOMINANT ALZHEIMER DISEASE DUE TO MUTATION OF PRESENILIN 1 (DISORDER) AUTOSOMAL DOMINANT ALZHEIMER DISEASE DUE TO MUTATION OF PRESENILIN 2 (DISORDER)