E-Cigarettes vs. regular smokes: which delivers more nicotine?

NCT ID NCT05457634

First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 28 times

Summary

This study looked at how much nicotine people get from blu disposable e-cigarettes compared to their usual brand of regular cigarettes. Twenty adult smokers used both products in controlled sessions, and researchers measured nicotine levels in their blood and their urge to smoke. The goal was to see if e-cigarettes might be less addictive and a better option for harm reduction.

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Contacts and locations

Locations

  • LA Clinical Trials, LLC

    Burbank, California, 91505, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

blu disposable e-cigarettes (2.4% nicotine) and combustible cigarettes

What this could lead to

If successful, this study could show that blu e-cigarettes deliver less nicotine and have lower abuse potential than regular cigarettes, supporting their use as a less harmful alternative for smokers.

What could go wrong

This is a small, completed study with only 20 healthy smokers, so results may not apply to all smokers. It measures short-term effects, not long-term health outcomes or addiction risk.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.