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Ultrasound probes hidden heart vessel damage after stents

NCT ID NCT07805187

Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This study tests whether ultrasound can detect problems in the heart's tiny blood vessels after a stent procedure. About 20 to 30 percent of people still feel chest pain after a successful stent, and doctors suspect small vessel dysfunction may be the cause. Researchers will compare blood flow in the treated artery versus untreated arteries to see if the issue is local or widespread. Participants will undergo non-invasive stress tests within four weeks after their stent and be followed for six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Coronary flow reserve measured by transthoracic Doppler echocardiography during stress tests (hyperventilation, cold pressor, dipyridamole)
What this could lead to
If it works, this could clarify why some people still have chest pain after a stent and point toward better ways to diagnose and treat small vessel problems.
What could go wrong
This is a small, early study with only 32 participants, so results may not apply to everyone. The tests measure blood flow but do not directly prove what causes symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Invasive coronary angiography and PCI performed within the previous 4 weeks from enrollment; * Obstructive single-vessel CAD (\>75% coronary diameter reduction or fractional flow reserve \<0.80) treated with PCI. Exclusion Criteria: * Presentation as an acute coronary syndrome (i.e. unstable angina or myocardial infarction) or a typical history of variant angina (frequent angina pain at rest with ST-segment elevation at the ECG, caused by recurrent coronary spasm); * Previous history of specific heart disease, e.g., ischemic (previous percutaneous or surgical myocardial revascularization, myocardial infarction), valvular, congenital heart disease or cardiomyopathy; * Multivessel coronary artery disease; * Serious medical conditions, including renal failure (eGFR \<30 mL/min), liver diseases, malignancies, and acute or chronic inflammatory diseases; * Contraindication to dipyridamole; * Pregnancy; * Psychological conditions that might interfere with patient co-operation; * Any condition that, in the judgment of the investigators, would make difficult for the patient to complete the study protocol; * Refusal to sign the informed consent.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pci patients Single coronary vessel disease

How to take part

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  1. The official record

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