Spinal injection may prevent brain damage after aneurysm

NCT ID NCT06329635

Recruiting now Disease control Sponsor: The Affiliated Hospital Of Guizhou Medical University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether injecting the drug nicardipine into the spinal fluid can improve recovery in people who develop blood vessel spasms after a brain aneurysm bleed. About 396 adults aged 18–80 will receive either the drug or a sham procedure. The goal is to see if the treatment reduces long-term disability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicardipine
What this could lead to: If it works, this could provide a new way to treat dangerous blood vessel spasms after a brain aneurysm bleed, potentially reducing disability.
What could go wrong: This is a mid-stage trial with 396 participants, so results are not yet proven. The treatment involves a spinal injection, which carries risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage intracranial vasospasm subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEURYSMAL SUBARACHNOID HEMORRHAGE VASOSPASM

Contacts and locations

Locations

Affiliated First Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230000, China
Affiliated South China Hospital of Shenzhen University
RECRUITING

Shenzhen, Guangdong, 518111, China
Baotou Central Hospital
RECRUITING

Baotou, Inner Mongolia, 014040, China
Beijing Tiantan Hospital, Affiliated to Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100070, China
Changzhou First People's Hospital
RECRUITING

Changzhou, Jiangsu, 213004, China
Chongqing Ninth People's Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400799, China
Ganzhou People's Hospital
RECRUITING

Ganzhou, Jiangxi, 341000, China
Jinggangshan University Affiliated Hospital
RECRUITING

Ji’an, Jiangxi, 343099, China
Jinyang Hospital Affiliated to Guizhou Medical University
RECRUITING

Guiyang, Guizhou, 550080, China
Liupanshui City People's Hospital
RECRUITING

Liupanshui, Guizhou, 553400, China
Nanning First People's Hospital
RECRUITING

Nanning, Guangxi, 530016, China
Nanyang Central Hospital, Henan Province
RECRUITING

Nanyang, Henan, 473005, China
People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture, Guizhou Province
RECRUITING

Xingyi, Guizhou, 558000, China
Qianfengdong Prefecture People's Hospital
RECRUITING

Kaili, G, 556099, China
Qianxinan Prefecture People's Hospital
RECRUITING

Xingyi, Guizhou, 562499, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 201112, China
Southern Medical University Zhujiang Hospital
RECRUITING

Guangzhou, Guangdong, 510260, China
Taian Central Hospital, Shandong Province
RECRUITING

Tai’an, Shandong, 27109, China
The First Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310000, China
The First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, Shanxi, 030001, China
The First People's Hospital of Zhenjiang City, Jiangsu Province
RECRUITING

Zhenjiang, Jiangsu, 212002, China
The Second Affiliated Hospital of Guizhou Medical University
RECRUITING

Kaili, Guizhou, 556099, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China
The Second Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 230601, China
West China Airport Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610299, China
Western Medical University Affiliated Hospital
RECRUITING

Luzhou, Sichuan, 646099, China
Xingyi City People's Hospital
RECRUITING

Xingyi, Guizhou, 562499, China
Zhejiang Hospital
RECRUITING

Hangzhou, Zhejiang, 310007, China

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