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Can targeted brain zaps boost stroke recovery?

NCT ID NCT07786649

Disease control Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This study tests whether personalized non-invasive brain stimulation (NIBS) can improve motor and language recovery in stroke patients. Participants receive either transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) over a month, tailored to their specific impairments. The goal is to see if matching stimulation type and brain area to each patient's needs leads to better outcomes in movement, speech, and attention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-invasive brain stimulation (NIBS) using transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If successful, this could lead to more personalized and effective brain stimulation protocols to improve movement, language, and attention recovery after stroke.
What could go wrong
The trial is early-stage and results may vary widely between individuals. There is also a risk that tailored protocols may not outperform standard approaches or that benefits may not last beyond the follow-up period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 21-80 years old; 2. Diagnosis of stroke, with good premorbid function. 3. Presenting with at least 1 of the following functional impairment: 3a. Upper limb motor impairment with the sum of Medical Research Council grades for shoulder abduction and finger Extension (SAFE) ≤ 8; 3b. Lower limb motor impairment with Functional Ambulation Classification (FAC) 0-3; 3c. Neglect as assessed by Behavioural Inattention Test with a cut-off of \<129 and Catherine Bergego Scale with a cut-off of \>5/30 3d. Expressive Aphasia as indicated by AusTOMS score of 1-4 (mild to severe) in the Language and Speech scales 4. Being able to follow instruction and give consent. Exclusion Criteria: 1. Pregnancy; 2. cardiac pacemakers; 3. Sensorimotor disturbance due to other causes other than stroke; 4. Uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina; 5. Major depression and a history of psychotic disorders; 6. Terminal diagnosis with life expectancy \<=1 year; 7. Claustrophobia for those undergoing fMRI scan. 8. Cognitive impairment and not being able to follow instruction.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alexandra Hospital

    RECRUITING

    Singapore, 159964, Singapore

  • National University Hospital

    RECRUITING

    Singapore, 119228, Singapore

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