Could a common vitamin boost brain cancer treatment?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults, 18 years old to 75 years old inclusive. * New diagnoses of glioblastoma IDH wild type. * ECOG 0-2 (Appendix I). * Candidates for concurrent standard first line treatment according to their Neuro-Oncologist and Radiotherapy Oncologist after maximal safe debulking neurosurgery. Patients that only had biopsy are included as long as pathology confirms the diagnoses and it is considered the maximal safe procedure for that patient. * Adequate hematological, renal and hepatic function (see details in Section 4.1 of the protocol). * Absence of known human immunodeficiency virus (HIV) infection, chronic hepatitis B or hepatitis C infection. * Absence of any other serious medical condition according to the medical judgment of the Qualified Investigator prior to registration. * Absence of any medical condition, which could interfere with oral medication intake. * Signed informed consent. * Patients must be accessible for treatment and follow-up. Patients registered on this trial must be treated and followed at the participating centre. * Women/men of childbearing potential must have agreed to use a highly effective contraceptive method. Exclusion Criteria: * Glioblastoma, IDH-mutant. * Patients with a history of other malignancies, except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumours curatively treated with no evidence of disease for ≥ 5 years. Additionally, any low grade or low risk malignancy not requiring treatment will not exclude a patient from participation in the trial. * Known hypersensitivity to niacin. * Inability to provide informed consent. * Active liver disease or unexplained persistent elevations of serum transaminases. * Active peptic ulcer or active gastrointestinal bleeding. * Unstable angina or myocardial infarction within 6 months. * Symptomatic gout. * Patients on 3-hydroxy-3-methylglutaryl-coenzyme (HMG-COA reductase) inhibitors that cannot discontinue them at least 2 weeks before starting Niacin CRT™. * Any prior systemic treatment for glioblastoma (standard, evidence based or experimental) or radiotherapy/radiosurgery. * Individuals with MRI non-compatible metal in the body, or unable to undergo MRI procedures including allergy to gadolinium. * Patients unfit for any treatment component, including contraindications for radiotherapy or Connective Tissue Disease. * Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. * Has known psychiatric or substance abuse disorders that would interfere with compliance with the requirements of the trial. * Pregnant, breast-feeding, unable and/or unwilling to use contraception methods.