New drug trial aims to shrink debilitating nerve tumors

NCT ID NCT03962543

Ongoing Disease control Sponsor: SpringWorks Therapeutics, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing an oral drug called mirdametinib for people with neurofibromatosis type 1 (NF1) who have painful, inoperable nerve tumors called plexiform neurofibromas. The main goal is to see if the drug can shrink these tumors by at least 20% and reduce pain and other symptoms. The trial includes 114 children and adults and is currently in its later testing phase.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AdventHealth Pediatric Oncology Hematology at Orlando

Orlando, Florida, 32804, United States
Albany Medical Center

Albany, New York, 12208, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Children's Healthcare of Atlanta - Center for Advanced Pediatrics

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital at Montefiore

The Bronx, New York, 10467, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Pittsburgh UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of The King's Daughters

Norfolk, Virginia, 23510, United States
Children's Medical Center

Dallas, Texas, 75235, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
IU Health Brain Tumor Infusion Clinic

Indianapolis, Indiana, 46202, United States
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
Kosair Charities Pediatric Clinical Research Unit

Louisville, Kentucky, 40202, United States
Lucile Packard Children's Hospital Stanford

Palo Alto, California, 94304, United States
MACC Fund Research Center

Milwaukee, Wisconsin, 53226, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nemours A. I. duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Orlando Health, Inc.

Orlando, Florida, 32806, United States
St. Joseph's Univeristy Medical Center

Paterson, New Jersey, 07503, United States
Swedish Medical Center - Cherry Hill Campus

Seattle, Washington, 98122, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
UCLA Oncology Center

Los Angeles, California, 90095, United States
UNC Medical Center

Chapel Hill, North Carolina, 27514, United States
UVA Health, Division of Neuro-Oncology

Charlottesville, Virginia, 22903, United States
University of Alabama at Birmingham/Children's of Alabama

Birmingham, Alabama, 35233, United States
University of California - Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of California - Irvine Health

Orange, California, 92868-3201, United States
University of Chicago Medical Centers

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Florida Clinical Research Center

Gainesville, Florida, 32610, United States
University of Illinois Hospital and Health Systems

Chicago, Illinois, 60612, United States
University of Iowa Hospitals & Clinics

Iowa City, Iowa, 52242, United States
University of Michigan CS Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Oklahoma Health Sciences Center, Jimmy Everest Center for Cancer and Blood Disorders in Children

Oklahoma City, Oklahoma, 73104, United States
University of Utah, Center for Clinical and Translational Sciences

Salt Lake City, Utah, 84108, United States
Washington University School of Medicine-Siteman Cancer Center

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

NEUROFIBROMATOSIS TYPE 1 (NF1) PLEXIFORM NEUROFIBROMA