Springworks Therapeutics, Inc.

This study aims to understand how the approved desmoid tumor drug nirogacestat affects ovarian function and fertility in premenopausal women. It will enroll 50 women aged 18-40 to monitor their menstrual cycles and hormone levels while taking the medication. The goal is to measur…

This study is testing an oral medication called nirogacestat in Japanese adults whose desmoid tumors are growing. Desmoid tumors are rare, non-cancerous growths that can cause pain and limit movement. The goal is to see if the drug can shrink these tumors and is safe for this spe…

This is the first study in people to test a new oral drug called SW-682. It aims to find a safe and effective dose for adults with advanced solid tumors that have stopped responding to other treatments. The study will focus on patients whose tumors have specific genetic changes i…

This early-stage study aims to understand how a drug called nirogacestat affects the way the body processes several other common medications. It will involve 16 healthy adult male volunteers who will take nirogacestat along with a specific set of test drugs. The main goal is to m…

This is an early-phase study to see if common heartburn medicines (famotidine/Pepcid and rabeprazole/Aciphex) change how the body processes an experimental cancer drug called nirogacestat. It will enroll 24 healthy adult men to measure drug levels and check for safety. The goal i…