Double-Drug attack on diabetes: can new combo save insulin cells?
NCT ID NCT03929601
Summary
This study is testing whether giving two immune-modulating drugs (rituximab-pvvr followed by abatacept) is better than one drug alone for people recently diagnosed with type 1 diabetes. The main goal is to see if the combination helps the body preserve its own ability to make insulin for a longer time after diagnosis. Researchers will measure insulin production, blood sugar control, and safety over two years.
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Contacts and locations
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Locations
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Barbara Davis Center for Childhood Diabetes
Aurora, Colorado, 80045, United States
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Benaroya Research Institute
Seattle, Washington, 98101, United States
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Childrens Hospital of Orange County
Orange, California, 92868, United States
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Columbia University
New York, New York, 10032, United States
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Indiana University - Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
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Queensland Children's Hospital
South Brisbane, Queensland, 4101, Australia
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Sanford Children's Specialty Clinic
Sioux Falls, South Dakota, 57105, United States
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Stanford University
Palo Alto, California, 94304, United States
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The Children's Mercy Hospital
Kansas City, Kansas, 64114, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Miami
Maimi, Florida, 33136, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pittsburg
Pittsburgh, Pennsylvania, 15224, United States
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University of Texas Southwestern
Dallas, Texas, 75390, United States
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Vanderbilt Eskind Diabetes Center
Nashville, Tennessee, 37232, United States
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Walter and Eliza Hall Institute of Medical Research
Melbourne, Victoria, 3050, Australia
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Yale University
New Haven, Connecticut, 06520, United States
Conditions
Explore the condition pages connected to this study.