Major trial tests targeted therapy for aggressive digestive cancers

NCT ID NCT07431281

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is testing whether adding new targeted drugs to standard chemotherapy works better for people with advanced stomach, esophageal, or gastroesophageal junction cancers. The trial is specifically for patients whose cancers test positive for a protein called CLDN18.2 but negative for HER2. Researchers will compare different drug combinations to see which helps patients live longer without their cancer worsening.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

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Phoenix, Arizona, 85054, United States
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Duarte, California, 91010, United States
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La Jolla, California, 92093, United States
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Orange, California, 92868, United States
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Walnut Creek, California, 94598, United States
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Lone Tree, Colorado, 80124, United States
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New Haven, Connecticut, 06510, United States
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Newark, Delaware, 19713, United States
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Washington D.C., District of Columbia, 20007, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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St. Petersburg, Florida, 33705, United States
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West Palm Beach, Florida, 33401, United States
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Atlanta, Georgia, 30309, United States
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Atlanta, Georgia, 30322, United States
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Atlanta, Georgia, 30342, United States
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Chicago, Illinois, 60637, United States
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Niles, Illinois, 60714, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40207, United States
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Boston, Massachusetts, 02114, United States
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Grand Rapids, Michigan, 49503, United States
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Burnsville, Minnesota, 55337, United States
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Rochester, Minnesota, 55905, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63110, United States
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East Brunswick, New Jersey, 08816, United States
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Hackensack, New Jersey, 07601, United States
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Summit, New Jersey, 07901, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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The Bronx, New York, 10461, United States
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The Bronx, New York, 10468, United States
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White Plains, New York, 10601, United States
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Winston-Salem, North Carolina, 27103, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43221, United States
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Portland, Oregon, 97213, United States
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Portland, Oregon, 97239, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Pittsburgh, Pennsylvania, 15240, United States
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Wilkes-Barre, Pennsylvania, 18711, United States
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Sioux Falls, South Dakota, 57105, United States
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Memphis, Tennessee, 38104, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75246, United States
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Sherman, Texas, 75090, United States
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Blacksburg, Virginia, 24060, United States
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Fairfax, Virginia, 22031, United States
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Falls Church, Virginia, 22042, United States
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Fort Belvoir, Virginia, 22060, United States
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Richmond, Virginia, 23219, United States
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Seattle, Washington, 98104, United States
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Charleston, West Virginia, 25315, United States
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SUSPENDED

Darlinghurst, 2010, Australia
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Garran, 2605, Australia
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Heidelberg, 3084, Australia
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Murdoch, 6150, Australia
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Randwick, 2031, Australia
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Westmead, 2145, Australia
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Linz, 4010, Austria
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Rankweil, 6830, Austria
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Vienna, 1090, Austria
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Wiener Neustadt, 2700, Austria
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Brussels, 1200, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Barretos, 14784-400, Brazil
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Fortaleza, 60336-045, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 91350200, Brazil
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Salvador, 41.950-610, Brazil
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Santa Maria, 97015-450, Brazil
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São Paulo, 01246-000, Brazil
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Vitória, 29043-260, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Abbotsford, British Columbia, V2S0C2, Canada
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Vancouver, British Columbia, VSZ 4E6, Canada
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Winnipeg, Manitoba, R3E 0V9, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Beijing, 100032, China
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Beijing, 100050, China
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Beijing, 100142, China
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Beijing, 102200, China
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Changde, 415000, China
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Chengdu, 610041, China
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Chongqing, 400016, China
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Fuzhou, 350005, China
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Fuzhou, 350011, China
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Guangzhou, 510655, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Hangzhou, 310020, China
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Harbin, 150081, China
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Hefei, 230031, China
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Hohhot, 010020, China
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Jinan, 2501117, China
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Kunming, 650118, China
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Lanzhou, 730000, China
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Linhai, 317000, China
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Linyi, 276000, China
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Nanchang, 330000, China
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Nanchang, 330029, China
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Nanjing, 2100008, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Nantong, 226361, China
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Shanghai, 200025, China
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Shanghai, 200127, China
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Shanghai, 20032, China
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Shantou, 515041, China
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Shenyang, 110016, China
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Shenzhen, 518036, China
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Tianjin, 300050, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Xi'an, 710068, China
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Xiamen, 361003, China
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Xingtai, 054031, China
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Xuzhou, 221009, China
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Yinchuan, 750004, China
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Zhengzhou, 450008, China
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Augsburg, 86156, Germany
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Essen, 45122, Germany
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Frankfurt, 60488, Germany
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Freiburg im Breisgau, 79106, Germany
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Hamburg, 20249, Germany
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Heidelberg, 69120, Germany
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Heilbronn, 74078, Germany
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Leipzig, 04103, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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Moers, 47441, Germany
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München, 81657, Germany
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Stuttgart, 70376, Germany
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Ulm, 89081, Germany
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Budapest, 1083, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Gyula, 5700, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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Zalaegerszeg, 8900, Hungary
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Ahmedabad, 380060, India
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Bhubaneshwar, 751019, India
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Hyderabad, 500032, India
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Mohali, 160055, India
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Mumbai, 400012, India
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New Delhi, 110017, India
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New Delhi, 110060, India
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Varanasi, 221005, India
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Vijayawada, 520002, India
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Milan, 20162, Italy
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Padua, 35128, Italy
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Rozzano, 20089, Italy
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Tricase, 73039, Italy
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Hirakata-shi, 573-1191, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kurashiki-shi, 710-8602, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakai, 590-0197, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 232-0024, Japan
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Gdansk, 80-219, Poland
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Koszalin, 75-581, Poland
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Krakow, 31-501, Poland
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Lublin, 20-080, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-034, Poland
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San Juan, 00921, Puerto Rico
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Daegu, 41404, South Korea
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Hwasun-gun, 58128, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8036, Spain
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Madrid, 28041, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Santiago de Compostela, 15706, Spain
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Valencia, 46010, Spain
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RECRUITING

Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
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Taichung, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 22000, Thailand
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Muang, 70000, Thailand
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Ankara, 06530, Turkey (Türkiye)
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Antalya, 07100, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34854, Turkey (Türkiye)
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Medreseboğazı, 01250, Turkey (Türkiye)
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Şahinbey, 27310, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, EC1A 7BE, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Oxford, OX3 7LE, United Kingdom

Conditions

Explore the condition pages connected to this study.

ESOPHAGEAL CANCER GASTRIC CANCER GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA