Head-to-Head showdown: new Weight-Loss drug takes on established rival

NCT ID NCT06662383

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Apr 19, 2026 · Last updated Apr 19, 2026

Summary

This study is testing whether a new weight-loss drug called retatrutide works better than an existing drug called tirzepatide for adults with obesity. About 800 participants will receive one of the two medications for 89 weeks. Researchers will measure how much weight people lose and check for improvements in cholesterol, blood pressure, and quality of life.

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Contacts and locations

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Locations

Accellacare - Wilmington

Wilmington, North Carolina, 28401, United States
Albany Medical College, Division of Community Endocrinology

Albany, New York, 12203, United States
AmBeNet GmbH

Leipzig, Saxony, 04107, Germany
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Bridgeport Hospital

Bridgeport, Connecticut, 06610, United States
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina
Centro Médico Viamonte

Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina
Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, C1056ABI, Argentina
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, Łódź Voivodeship, 90-338, Poland
Centrum Zdrowia Metabolicznego Pawel Bogdanski

Poznan, Greater Poland Voivodeship, 60-589, Poland
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Chrysalis Clinical Research

St. George, Utah, 84790, United States
ClinCept Clinical Research - MH

Columbus, Georgia, 31904, United States
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
Consultorio de Investigación Clínica EMO SRL

Buenos Aires, Buenos Aires F.D., C1405BUB, Argentina
DIM Clínica Privada

Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Diabetes Zentrum Wilhelmsburg

Hamburg, 21109, Germany
Diabeteszentrum Hamburg West

Hamburg, 22607, Germany
Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz

Lingen, Lower Saxony, 49808, Germany
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
Einstein Clinical Research

Vero Beach, Florida, 32960, United States
Ekamed

Lublin, Lublin Voivodeship, 20-718, Poland
Encompass Clinical Research

Spring Valley, California, 91978, United States
Encore Medical Research

Hollywood, Florida, 33024, United States
Gabinet Leczenia Otylosci i Chorob Dietozaleznych - dr hab. n. med. Lucyna Ostrowska

Bialystok, Podlaskie Voivodeship, 15-281, Poland
Gabinety TERPA

Lublin, Lublin Voivodeship, 20-333, Poland
Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob

Villingen-Schwenningen, Baden-Wurttemberg, 78048, Germany
Great Lakes Research Group, Inc.

Bay City, Michigan, 48706, United States
Great Lakes Research Institute

Southfield, Michigan, 48075, United States
Headlands Horizons LLC

Brownsville, Texas, 78526, United States
Houston Research Institute

Houston, Texas, 77079, United States
InnoDiab Forschung Gmbh

Essen, North Rhine-Westphalia, 45136, Germany
Integrated Clinical Trial Services, Inc.

West Des Moines, Iowa, 50265, United States
Las Vegas Endocrinology

Henderson, Nevada, 89074, United States
Lillestol Research

Fargo, North Dakota, 58104, United States
Lynn Institute of Denver

Aurora, Colorado, 80012, United States
Mary & Dick Allen Diabetes Center

Newport Beach, California, 92663, United States
Medical Advancement Centers of Arizona

Tempe, Arizona, 85283, United States
Medizentrum Essen Borbeck

Essen, North Rhine-Westphalia, 45355, Germany
Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

Ruda Śląska, Silesian Voivodeship, 41-709, Poland
NZOZ Specjalistyczny Ośrodek Internistyczno-Diabetologiczny

Bialystok, Podlaskie Voivodeship, 15-435, Poland
New York Gastroenterology Associates

New York, New York, 10075, United States
Next Level Urgent Care

Houston, Texas, 77057, United States
Northeast Georgia Medical Center

Gainesville, Georgia, 30501, United States
Northwestern University

Chicago, Illinois, 60611, United States
Nzoz Neuro-Kard Ilkowski i Partnerzy SPL

Poznan, Greater Poland Voivodeship, 61-853, Poland
Onhealth Research Center

Miami, Florida, 33186, United States
Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States
PharmQuest Life Sciences, LLC

Greensboro, North Carolina, 27408, United States
Pivotal Research Solutions

Stonecrest, Georgia, 30038, United States
Ponce Medical School Foundation Inc.

Ponce, 00716, Puerto Rico
Precision Clinical Research

Sunrise, Florida, 33351, United States
PriMED Clinical Research

Dayton, Ohio, 45429, United States
RED-Institut GmbH

Oldenburg in Holstein, Schleswig-Holstein, 23758, Germany
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
Suncoast Research Group

Miami, Florida, 33135, United States
Tribe Clinical Research, LLC

Greenville, South Carolina, 29607, United States
Uniwersytecki Szpital Kliniczny w Białymstoku

Bialystok, Podlaskie Voivodeship, 15-276, Poland
WR-Clinsearch, LLC

Chattanooga, Tennessee, 37421, United States
Westchester Medical Center

Valhalla, New York, 10595, United States
Yale University School of Medicine

New Haven, Connecticut, 06519, United States
Zdrowie Osteo-Medic

Bialystok, Podlaskie Voivodeship, 15-351, Poland
Zentrum fur klinische Forschung - Köln

Cologne, North Rhine-Westphalia, 51069, Germany

Conditions

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OBESITY