Hope for kids with tough cancer: new combo trial launches

NCT ID NCT07261241

Not yet recruiting Disease control Sponsor: New Approaches to Neuroblastoma Therapy Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests three different combinations of a radioactive drug (131I-MIBG) with other medicines (vorinostat and/or dinutuximab) in children and young adults with relapsed or refractory neuroblastoma. About 118 participants will be randomly assigned to one of three treatment arms to see which combination shrinks tumors best. The goal is to find a more effective treatment for this hard-to-treat cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 131I-MIBG (radioactive drug) combined with vorinostat and/or dinutuximab
What this could lead to: If successful, this trial could identify a more effective combination therapy for relapsed or refractory neuroblastoma, potentially improving tumor response rates.
What could go wrong: This is a phase 2 trial with only 118 participants, so results are preliminary. The treatments involve significant side effects, including high-grade toxicities, and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuroblastoma nodular ganglioneuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROBLASTOMA

Contacts and locations

Locations

C.S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Children Hospital of Colorado

Aurora, Colorado, 80045, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027-0700, United States
Children's Hospital and Regional Medical Center - Seattle

Seattle, Washington, 98105, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104-4318, United States
Children's Memorial Hospital - Chicago

Chicago, Illinois, 60614, United States
Childrens Hospital Boston, Dana-Farber Cancer Institute.

Boston, Massachusetts, 02115, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229-3039, United States
Cook Children's Medical Center - Fort Worth

Fort Worth, Texas, 76104, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94143, United States
University of Texas Southwestern

Dallas, Texas, 75235, United States

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