New hope for Tough-to-Treat endometrial cancer: targeted drug enters major global trial

NCT ID NCT07044336

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing whether a new targeted drug called puxitatug samrotecan helps people with advanced endometrial cancer live longer or live longer without their cancer getting worse, compared to standard chemotherapy. It is for people whose cancer has continued to grow despite prior platinum-based chemotherapy and immunotherapy. About 700 participants worldwide will be randomly assigned to receive either the new drug or a standard chemotherapy chosen by their doctor.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Tucson, Arizona, 85719, United States
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La Jolla, California, 92037, United States
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Los Angeles, California, 90095, United States
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Orange, California, 92868, United States
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Jupiter, Florida, 33458, United States
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Miami, Florida, 33136, United States
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Miami, Florida, 33176, United States
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Miami Beach, Florida, 33140, United States
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Orlando, Florida, 32806, United States
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West Palm Beach, Florida, 33401, United States
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Honolulu, Hawaii, 96826, United States
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Chicago, Illinois, 60607, United States
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Peoria, Illinois, 61637, United States
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Urbana, Illinois, 61801, United States
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Fort Wayne, Indiana, 46845, United States
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Indianapolis, Indiana, 46260, United States
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Scarborough, Maine, 04074, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21231, United States
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Silver Spring, Maryland, 20910, United States
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Ann Arbor, Michigan, 48109, United States
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Ann Arbor, Michigan, 48197, United States
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Detroit, Michigan, 48201, United States
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Minneapolis, Minnesota, 55404, United States
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Camden, New Jersey, 08103, United States
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Paramus, New Jersey, 07652, United States
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Albuquerque, New Mexico, 87109, United States
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Brooklyn, New York, 11220, United States
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Stony Brook, New York, 11794, United States
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The Bronx, New York, 10461, United States
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White Plains, New York, 10601, United States
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Greenville, North Carolina, 27834, United States
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Pinehurst, North Carolina, 28374, United States
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Cincinnati, Ohio, 45220, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44109, United States
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Columbus, Ohio, 43219, United States
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Dayton, Ohio, 45459, United States
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Hilliard, Ohio, 43026, United States
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Sylvania, Ohio, 43560, United States
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Portland, Oregon, 97239, United States
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Bethlehem, Pennsylvania, 18015, United States
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Hershey, Pennsylvania, 17033, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Pittsburgh, Pennsylvania, 15224, United States
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Willow Grove, Pennsylvania, 19090, United States
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Sioux Falls, South Dakota, 57104, United States
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Sioux Falls, South Dakota, 57105, United States
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Knoxville, Tennessee, 37920, United States
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Nashville, Tennessee, 37232, United States
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Austin, Texas, 78758, United States
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Houston, Texas, 77030, United States
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Tyler, Texas, 75702, United States
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Fairfax, Virginia, 22031, United States
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Falls Church, Virginia, 22042, United States
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Norfolk, Virginia, 23502, United States
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Richmond, Virginia, 23298, United States
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Roanoke, Virginia, 24016, United States
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Kennewick, Washington, 99336, United States
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Seattle, Washington, 98104, United States
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Morgantown, West Virginia, 26505, United States
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Waukesha, Wisconsin, 53188, United States
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Capital Federal, C1417DTB, Argentina
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Ciudad Autonoma Buenos Aires, 1405, Argentina
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Ciudad de Buenos Aires, C1118AAT, Argentina
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Córdoba, 2356, Argentina
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Córdoba, X5004FHP, Argentina
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Cuidad Autónoma de Buenos Aire, C1426ANZ, Argentina
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La Rioja, 5300, Argentina
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Pergamino, B2700CPM, Argentina
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Viedma, R8500ACE, Argentina
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Malvern, 3144, Australia
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Melbourne, 3000, Australia
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Randwick, 2031, Australia
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St Leonards, 2065, Australia
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Subiaco, 6008, Australia
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Westmead, 2145, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Vienna, 1090, Austria
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Brussels, 1070, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6000, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Belém, 66073-005, Brazil
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Blumenau, 89010-340, Brazil
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Curitiba, 80510-130, Brazil
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Curitiba, 80810-050, Brazil
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Florianópolis, 88020-210, Brazil
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Natal, 59062-000, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90470-340, Brazil
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Porto Alegre, 90610-001, Brazil
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Recife, 50070-480, Brazil
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Rio de Janeiro, 22281-100, Brazil
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Rio de Janeiro, 22775-001, Brazil
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Salvador, 41950-640, Brazil
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São Caetano do Sul, 09541-270, Brazil
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São Paulo, 01317-000, Brazil
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São Paulo, 01323-020, Brazil
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São Paulo, 01509-900, Brazil
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Sorocaba, 18030-005, Brazil
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Sorocaba, 18052-210, Brazil
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Taubaté, 12030-200, Brazil
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Teresina, 64049-200, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Kingston, Ontario, K7L 2V7, Canada
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Montreal, Quebec, H2X 0C1, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Beijing, 100021, China
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Beijing, 100026, China
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Beijing, 100044, China
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Beijing, 100730, China
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Changchun, 130021, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Dalian, 116023, China
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Fuzhou, 350014, China
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Guangzhou, 510120, China
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Hangzhou, 310006, China
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Hangzhou, 310022, China
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Jinan, 250012, China
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Jinan, 250117, China
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Nanchang, 330006, China
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Nanjing, 210004, China
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Shanghai, 200011, China
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Shanghai, 200025, China
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Shanghai, 200072, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Shenzhen, 518116, China
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Shijiazhuang, 050011, China
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Tianjin, 300060, China
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Tianjin, 300110, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Zhengzhou, 450002, China
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Brno, 625 00, Czechia
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Brno, 656 53, Czechia
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Hradec Králové, 500 05, Czechia
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Nový Jičín, 74101, Czechia
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Ostrava, 708 502, Czechia
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Prague, 12808, Czechia
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Prague, 180 81, Czechia
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V Uvalu 84, 150 06, Czechia
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Herlev, 2730, Denmark
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Kuopio, 70210, Finland
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Tampere, 33520, Finland
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Turku, 20520, Finland
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Avignon, 84918, France
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Besançon, 25000, France
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Bordeaux, 33076, France
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Chambray-lès-Tours, 37170, France
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Cholet, 49300, France
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Créteil, 94010, France
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Grenoble, 38000, France
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Lille, 59000, France
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Limoges, 87042, France
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Lyon, 69008, France
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Nantes, 44000, France
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Nîmes, 30029, France
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Paris, 75014, France
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Paris, 75020, France
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Paris, 75900, France
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Plerin SUR MER, 22190, France
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Rennes, 35000, France
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Toulouse, 31059, France
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Batumi, 6000, Georgia
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Tbilisi, 0159, Georgia
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Tbilisi, 0186, Georgia
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Amberg, 92224, Germany
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Chemnitz, 09116, Germany
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Dresden, 01307, Germany
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Essen, 45130, Germany
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Frankfurt am Main, 60596, Germany
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Freiburg im Breisgau, 79106, Germany
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Hamburg, 20246, Germany
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Heidelberg, 69120, Germany
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Heilbronn, 74078, Germany
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Mainz, 55131, Germany
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Münster, 48149, Germany
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Paderborn, 33161, Germany
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Regensburg, 93053, Germany
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Schwäbisch Hall, 74523, Germany
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Witten, 58452, Germany
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Athens, 115 28, Greece
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Athens, 11528, Greece
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Athens, 14564, Greece
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Thessaloniki, 55236, Greece
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Budapest, 1082, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Ashdod, 7747629, Israel
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Hadera, 38100, Israel
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Haifa, 3109601, Israel
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Holon, 5822012, Israel
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Jerusalem, 9103102, Israel
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Jerusalem, 9112001, Israel
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Nahariya, 2210001, Israel
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Ramat Gan, 5262000, Israel
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Safed, 13100, Israel
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Tel Aviv, 6423906, Israel
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Alessandria, 15121, Italy
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Aviano, 33081, Italy
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Bologna, 40138, Italy
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Catania, 95126, Italy
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Florence, 50134, Italy
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Haifa, 34362, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Milan, 20159, Italy
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Milan, 20162, Italy
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Milan, 35128, Italy
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Monza, 20900, Italy
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Napoli, 80131, Italy
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Parma, 43126, Italy
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Pisa, 56100, Italy
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Ponderano, 13875, Italy
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Roma, 00168, Italy
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Torino, 10128, Italy
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Vicenza, 36100, Italy
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Isehara-shi, 259-1193, Japan
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Kashiwa-shi, 277-8567, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Matsuyama, 791-0280, Japan
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Minatoku, 105-8471, Japan
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Nagoya, 464-8681, Japan
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Nakagami-gun, 903-0215, Japan
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Niigata, 951-8510, Japan
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Okayama, 700-8558, Japan
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Osaka, 637086, Japan
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Sapporo, 003-0804, Japan
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Sapporo, 060-8638, Japan
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Sendai, 980-8574, Japan
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Suita, 565-0871, Japan
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Sunto-gun, 411-8777, Japan
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Toon-Shi, 791-0295, Japan
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Tsu, 514-8507, Japan
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Yokohama, 236-0004, Japan
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Kaunas, LT50009, Lithuania
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Vilnius, 08661, Lithuania
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Vilnius, 8660, Lithuania
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Amsterdam, 1081 HV, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Lodz, 93-338, Poland
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Siedlce, 08-110, Poland
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Ljubljana, 1000, Slovenia
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Maribor, 2000, Slovenia
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Goyang-si, 410-769, South Korea
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Gwangjin-gu, 110-744, South Korea
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Seoul, 03722, South Korea
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Seoul, 06273, South Korea
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Seoul, 135-710, South Korea
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Songpa-gu, 05505, South Korea
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Suwon, 16499, South Korea
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Badalona, 8916, Spain
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Barcelona, 8025, Spain
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Barcelona, 8035, Spain
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Córdoba, 14004, Spain
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El Palmar (Murcia), 30120, Spain
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Hospitalet DEL Llobregat, 8908, Spain
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Madrid, 28033, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Oviedo, 33011, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41013, Spain
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Seville, 41014, Spain
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Valencia, 46010, Spain
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New Taipei City, 220, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 100, Taiwan
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Taipei, 10449, Taiwan
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Bebington, CH63 4JY, United Kingdom
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Canterbury, CT1 3NG, United Kingdom
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Derby, DE22 3NE, United Kingdom
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London, E1 1BB, United Kingdom
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London, W2 1NY, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Truro, TR1 3LJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

ENDOMETRIAL CANCER MALIGNANT SOLID TUMOUR