New drug targets breast cancer in the brain

NCT ID NCT07413939

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This study tests a new drug, RO7771950, designed to reach the brain, for people with HER2-positive breast cancer that has spread to the brain or other organs. About 650 participants will receive either the new drug or an existing drug (tucatinib), both combined with standard therapies. The goal is to see if the new drug can better delay cancer growth or improve survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7771950 (also called ZN-A-1041)
What this could lead to: If it works, this could offer a new treatment option for HER2-positive breast cancer that has spread to the brain, potentially improving how long people live without their cancer growing.
What could go wrong: This is an early-to-mid stage trial, so the new drug may not work better than the existing treatment. Side effects are possible, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE BREAST CANCER

Contacts and locations

Locations

A.O. Universitaria Di Parma
RECRUITING

Parma, Emilia-Romagna, 43100, Italy
AZ Groeninge
RECRUITING

Kortrijk, 8500, Belgium
AZ St Maarten Campus Leopoldstr
RECRUITING

Mechelen, 2800, Belgium
Abdurrahman Yurtarslan Onkoloji Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Acibadem Izmir Kent Hospital
RECRUITING

Izmir, 35630, Turkey (Türkiye)
Ajou University Medical Center
RECRUITING

Gyeonggi-do, 16499, South Korea
Akdeniz University Medical Faculty
RECRUITING

Antalya, 07058, Turkey (Türkiye)
Anhui Provincial Hospital
RECRUITING

Hefei, 230001, China
Ankara Bilkent City Hospital
RECRUITING

Ankara, 06490, Turkey (Türkiye)
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asst Degli Spedali Civili Di Brescia
RECRUITING

Brescia, Lombardy, 25123, Italy
Asst Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Lombardy, 20162, Italy
Asst Papa Giovanni XXIII
RECRUITING

Bergamo, Lombardy, 24127, Italy
Assula Medical Center
RECRUITING

Tel Aviv, 6971028, Israel
Auckland City Hospital, Cancer and Blood Research
RECRUITING

Auckland, 1023, New Zealand
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji
RECRUITING

Bakirkoy / Istanbul, 34147, Turkey (Türkiye)
Bangkok Metropolitan Administration Medical College and Vajira Hospital
RECRUITING

Wachira Phayaban, 10300, Thailand
Barwon Health
RECRUITING

Geelong, Victoria, 3220, Australia
Beijing Cancer Hospital
RECRUITING

Beijing, 100021, China
Bács-Kiskun Vármegyei Oktatókórház
RECRUITING

Kecskemét, 6000, Hungary
CHUM
RECRUITING

Montreal, Quebec, H2L 4M1, Canada
CHVNG/E_Unidade 1
RECRUITING

Vila Nova de Gaia, 4434-502, Portugal
Cancer Hospital Chinese Academy of Medical Sciences.
RECRUITING

Beijing, 100021, China
Centro Médico Fleischer
RECRUITING

Buenos Aires, C1414DRK, Argentina
Centro Oncología Precisión Iquique
RECRUITING

Iquique, 1111442, Chile
Centro Oncológico de Excelencia
RECRUITING

San Juan, J5402BGA, Argentina
Centro de Investigación Clínica UC-CICUC
RECRUITING

Santiago, 8330034, Chile
Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 5262000, Israel
Chang Gung Memorial Hospital - Linkou
RECRUITING

Taoyuan City, 333, Taiwan
Chris Hani Baragwanath Clinical Trial Site
RECRUITING

Soweto, 2013, South Africa
Christie Hospital Nhs Trust
RECRUITING

Manchester, M20 4GJ, United Kingdom
Chulabhorn Hospital
RECRUITING

Lak Si, 10210, Thailand
Clinique Ste-Elisabeth
RECRUITING

Namur, 5000, Belgium
Cliniques Universitaires St-Luc
RECRUITING

Brussels, 1200, Belgium
Complejo Hospitalario de Jaen
RECRUITING

Jaén, 23007, Spain
Debreceni Egyetem Klinikai Kozpont
RECRUITING

Debrecen, 4032, Hungary
Dolno?l?skie Centrum Onkologii
RECRUITING

Wroc?aw, 53-413, Poland
Dres. Andreas Köhler und Roswitha Fuchs
RECRUITING

Langen, 63225, Germany
Ege University Medical Faculty
RECRUITING

Bornova, Izmir, 35100, Turkey (Türkiye)
Faculty of Med. Siriraj Hosp.
RECRUITING

Bangkok, 10700, Thailand
Fakultni Nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice v Motole
RECRUITING

Prague, 150 06, Czechia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, Lazio, 00168, Italy
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, 350001, China
Fundación Respirar
RECRUITING

CABA, C1426AAL, Argentina
Guangxi Cancer Hospital of Guangxi Medical University
RECRUITING

Nanning, 530201, China
Hacettepe University Medical Faculty
RECRUITING

Altındağ, 06230, Turkey (Türkiye)
Hopital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Hopital du Saint Sacrement
RECRUITING

Québec, Quebec, G1S 4L8, Canada
Hospital Beatriz Angelo
RECRUITING

Loures, 2674-514, Portugal
Hospital Clinic Provincial
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28009, Spain
Hospital Pedro Hispano
RECRUITING

Matosinhos Municipality, 4454-509, Portugal
Hospital Professor Doutor Fernando Fonseca, E.P.E.
RECRUITING

Amadora-Lisbon, 2610-276, Portugal
Hospital Provincial del Centenario
RECRUITING

Rosario, S2002KDS, Argentina
Hospital Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario 12 De Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Basurto
RECRUITING

Bilbao, Vizcaya, 48013, Spain
Hospital Universitario San Cecilio
RECRUITING

Granada, 18016, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

EL Palmar (EL Palmar), Murcia, 30120, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, Tenerife, 38320, Spain
Hospital da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Hospital las Higueras
RECRUITING

Concepción, Región Bio Bio, Alto Horno 777, Chile
Hubei Cancer Hospital
RECRUITING

Wuhan, 430079, China
Humanitas Centro Catanese Di Oncologia
RECRUITING

Misterbianco (CT), Sicily, 95045, Italy
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, Lombardy, 20141, Italy
IOB Madrid Institute of Oncology Hospital Beata Maria Ana de Jesus;Unidad Central de Oncología Médica y de Investigación Oncológica
RECRUITING

Madrid, 28007, Spain
IPO de Lisboa
RECRUITING

Lisbon, 1099-023, Portugal
IPO do Porto
RECRUITING

Porto, 4200-072, Portugal
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Icegclinic
RECRUITING

Santiago, Chile
Ichilov Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
InVO - Institut für Versorgungsforschung in der Onkologie GbR
RECRUITING

Koblenz, 56068, Germany
Instituto Alexander Fleming
RECRUITING

Buenos Aires, C1426ANZ, Argentina
Instytut "Centrum Zdrowia Matki Polki"
RECRUITING

?ód?, 93-338, Poland
Investigaciones Clínicas Moleculares
RECRUITING

Buenos Aires, C1425BGH, Argentina
Irccs Centro Di Riferimento Oncologico (CRO)
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Irccs Istituto Nazionale Dei Tumori (Int)
RECRUITING

Milan, Lombardy, 20133, Italy
Istinye University Liv Hospital Topkapi
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Istituto Clinico Humanitas
RECRUITING

Rozzano, Lombardy, 20089, Italy
Jessa Zkh (Campus Virga Jesse)
RECRUITING

Hasselt, 3500, Belgium
Jiangmen Central Hospital
RECRUITING

Jiangmen, 529030, China
Leicester Royal Infirmary
RECRUITING

Leicester, LE2 7LG, United Kingdom
Lkh Salzburg - Univ. Klinikum Salzburg
RECRUITING

Salzburg, 5020, Austria
Lkh-Univ. Klinikum Graz
RECRUITING

Graz, 8036, Austria
Macquarie University Hospital
RECRUITING

Macquarie Park, New South Wales, 2113, Australia
Marien-Hospital Witten
RECRUITING

Witten, 58452, Germany
Marmara University Pendik Research and Training Hospital
RECRUITING

Istanbul, 34722, Turkey (Türkiye)
Masaryk?v onkologický ústav
RECRUITING

Brno, 656 53, Czechia
McGill University Health Centre - Glen Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medical Oncology Centre of Rosebank
RECRUITING

City of Johannesburg, 2196, South Africa
Medicina de Precisión - Celerity
RECRUITING

Las Condes, 7560908, Chile
Medikal Park Samsun
RECRUITING

Samsun, 55200, Turkey (Türkiye)
Mersin City Education and Research Hospital
RECRUITING

Mersin, 33240, Turkey (Türkiye)
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
NU-MED Centrum Diagnostyki i Terapii Onkologicznej
RECRUITING

Tomaszów Mazowiecki, 97-200, Poland
Nanchang People?s Hospital
RECRUITING

Nanchang, 330025, China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
RECRUITING

Nanjing, Jiangsu, 210031, China
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cheng Kung University Hospital
RECRUITING

Tainan, 00704, Taiwan
National Taiwan Uni Hospital
RECRUITING

Taipei, 10041, Taiwan
Oncovida
RECRUITING

Providencia, 7500994, Chile
Opolskie Centrum Onkologii
RECRUITING

Opole, 45-061, Poland
Ordensklinikum Linz Barmherzige Schwestern
RECRUITING

Linz, 4010, Austria
Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Margaret Cancer Center
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Rabin Medical Center
RECRUITING

Petah Tikva, 4910000, Israel
Ramathibodi Hospital
RECRUITING

Bangkok, 10400, Thailand
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
Rotkreuzklinikum München
RECRUITING

München, 80637, Germany
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital - Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Semmelweis Egyetem;Onkológiai Profil (Belgyógyászati és Onkológiai Klinika)
RECRUITING

Budapest, 1082, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Seoul St Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Shandong Cancer Hospital
RECRUITING

Jinan, 250117, China
Shantou Center Hospital
RECRUITING

Shantou, 515031, China
Songklanagarind Hospital
RECRUITING

Songkhla, 90110, Thailand
Srinagarind Hospital, Khon Kaen Uni
RECRUITING

Khon Kaen, 40002, Thailand
St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise
RECRUITING

Paderborn, 33098, Germany
Städtisches Klinikum Dessau
RECRUITING

Dessau, 06847, Germany
Sun yat-sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Sunnybrook Odette Cancer Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sunshine Hospital
RECRUITING

St Albans, Victoria, 3021, Australia
Szpital Kliniczny Ministerstwa Spraw Wewn?trznych i Administracji z Warmi?sko-Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, 10-228, Poland
Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 31202, Poland
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112201, Taiwan
Tauranga Hospital, Clinical Trials Unit
RECRUITING

Tauranga, 3112, New Zealand
The Second Affiliated Hospital of Zhejiang University College
RECRUITING

HangzhouZhejiang, 310009, China
The West Clinic, PC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
Trakya University Medical Faculty
RECRUITING

Erdine, 22030, Turkey (Türkiye)
Tumor Hospital of the affiliated medical college of Shantou University
RECRUITING

Shantou, 515000, China
UCLH
RECRUITING

London, WC1E 6AG, United Kingdom
UZ Leuven Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Università Campus Bio-Medico di Roma
RECRUITING

Rome, Lazio, 128, Italy
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Późna, 60569, Poland
Uniwersyteckie Centrum Kliniczne im. K. Gibinskiego SUM
RECRUITING

Katowice, 40-514, Poland
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
RECRUITING

Opole, 45-061, Poland
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
RECRUITING

Barcelona, 08035, Spain
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China
Yunnan Cancer Hospital
RECRUITING

Kunming, 650118, China
ZAS Sint Augustinus Wilrijk
RECRUITING

Wilrijk, 2610, Belgium
the First Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, 233000, China

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