New hope for stomach cancer: targeted drug combo enters final testing

NCT ID NCT07385703

Recruiting now Disease control Sponsor: Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing whether a new drug combination (tecotabart vedotin plus tislelizumab) works better than standard chemotherapy for people with advanced stomach cancer that has a specific protein called CLDN18.2. The study plans to enroll 752 participants who have not had prior treatment for their advanced cancer. The main goal is to see if the new combo delays cancer growth and improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tecotabart vedotin (LM-302) plus tislelizumab
What this could lead to: If successful, this could offer a new first-line treatment option for people with advanced stomach cancer that targets a specific protein (CLDN18.2), potentially improving how long they live without their cancer growing.
What could go wrong: This is an early-stage Phase 3 trial, so results are not yet known. The new drug combination may not work better than current chemotherapy, and side effects from the targeted therapy and immunotherapy could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOCARCINOMA

Contacts and locations

Locations

Affiliated Cancer Hospital of Harbin Medical University
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Affiliated Hospital Of Ji Ning Medical University
NOT_YET_RECRUITING

Jining, Shandong, 272029, China
Affiliated Hospital of Chengde Medical University
NOT_YET_RECRUITING

Chengde, Hebei, 067000, China
Affiliated Hospital of North Sichuan Medical College
NOT_YET_RECRUITING

Nanchong, Sichuan, 637000, China
Affiliated Hospital of Yangzhou Univrtsity
NOT_YET_RECRUITING

Yangzhou, Jiangsu, 225000, China
Affiliated Tumor Hospital of Xinjiang Medical University
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830000, China
Affiliated Zhongshan Hospital Of Dalian University
NOT_YET_RECRUITING

Dalian, Liaoning, 116001, China
Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230000, China
Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230000, China
Anhui Provincial Hospital (The First Affiliated Hospital of China University of Science and Technology)
NOT_YET_RECRUITING

Hefei, Anhui, 230000, China
Anyang Cancer Hospital
NOT_YET_RECRUITING

Anyang, Henan, 455000, China
Baoji Central Hospital
NOT_YET_RECRUITING

Baoji, Shaanxi, 721008, China
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beijing Friendship Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100050, China
Beijing Gaobo Hospital Co., Ltd.
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 102200, China
Beijing Lu He Hospital ,Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 101149, China
Beijing Tsinghua changgung Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 102218, China
Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute, Shandong Cancer Hospital)
NOT_YET_RECRUITING

Jinan, Shandong, 250000, China
Chang zhi People's Hospital
NOT_YET_RECRUITING

Changzhi, Shanxi, 046000, China
Chifeng Municipal Hospital
NOT_YET_RECRUITING

Chifeng, Inner Mongolia, 24000, China
China-Japan Union Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Chongqing University Three Gorges Hospital
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 404000, China
First Hospital Of Shan Xi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 30001, China
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 201321, China
Fujian Cancer Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350000, China
Fujian Medical University Union Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350000, China
Fujian Provincial Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350000, China
Gansu Provincial Cancer Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730050, China
Gansu Provincial Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730000, China
Gansu Wuwei Tumour Hospital
NOT_YET_RECRUITING

Wuwei, Gansu, 730000, China
Guangdong provincial people's hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
Guangxi Medical University Afiliated Tomor Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, 530000, China
Guigang City People's Hospital
NOT_YET_RECRUITING

Guigang, Guangxi, 537100, China
Hainan general hospital
NOT_YET_RECRUITING

Haikou, Hainan, 570311, China
Henan Provincial Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
Jiamusi Tuberculosis Hospital (Jiamusi Cancer Hospital)
NOT_YET_RECRUITING

Jiamusi, Heilongjiang, 154002, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210029, China
Jiangsu Provincial Cancer Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
Jiangxi Cancer Hospital
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330029, China
Jilin Cancer Hospital
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Jinan Central Hospital (City level)
NOT_YET_RECRUITING

Jinan, Shandong, 250000, China
Jingzhou First People's Hospital
NOT_YET_RECRUITING

Jingzhou, Hubei, 430000, China
Liaoning Cancer Hospital & Institute
NOT_YET_RECRUITING

Shenyang, Liaoning, 110801, China
Linyi Cancer Hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276034, China
Linyi People's Hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276000, China
Lishui Central Hospitall
NOT_YET_RECRUITING

Lishui, Zhejiang, 323000, China
Luoyang Central Hospital
NOT_YET_RECRUITING

Luoyang, Henan, 471000, China
Meizhou People's Hospital
NOT_YET_RECRUITING

Meizhou, Guangdong, 514000, China
Nanchang University First Affiliated Hospital
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
Nanjing Drum Tower Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
Nantong Tumor Hospital
NOT_YET_RECRUITING

Nantong, Jiangsu, 226300, China
Nanyang Second General Hospital
NOT_YET_RECRUITING

Nanyang, Henan, 473000, China
Peking University Cancer Hospital Inner Mongolia Hospita
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010000, China
Qingdao Municipal Hospital (Group)
NOT_YET_RECRUITING

Qingdao, Shandong, 266100, China
QinghaiI University Affiliated Hospital
NOT_YET_RECRUITING

Xining, Qinghai, 810000, China
Shaanxi Provincial People's Hospital
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
Shanghai General Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200001, China
Shanghai GoBroad Cancer Hospital China Pharmaceutical University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200131, China
Shantou University Medical College Affiliated Tumor Hospital
NOT_YET_RECRUITING

Shantou, Guangdong, 515000, China
Shanxi Cancer Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030000, China
Shengjing Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110001, China
Sichuan Academy of Medical Science&Sichuan Provincial People' Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610000, China
Sichuan Provincial Cancer Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310016, China
Subei People's Hospital of Jiangsu province
NOT_YET_RECRUITING

Yangzhou, Jiangsu, 225001, China
The Affiliated Hospital of Inner Mongolia Medical University
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010000, China
The Affiliated Hospital of Xuzhou Medical University
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221004, China
The First Affiliated Hospital Of Henan University of Science and Technology
NOT_YET_RECRUITING

Luoyang, Henan, 471000, China
The First Affiliated Hospital Of Wannan Medical College
NOT_YET_RECRUITING

Wuhu, Anhui, 241001, China
The First Affiliated Hospital Of Xi 'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital Of Xiamen University
NOT_YET_RECRUITING

Xiamen, Fujian, 361003, China
The First Affiliated Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310016, China
The First Affiliated Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110801, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400010, China
The First Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510030, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215006, China
The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830000, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730000, China
The First People's Hospital Of Changzhou
NOT_YET_RECRUITING

Changzhou, Jiangsu, 213000, China
The First affiliated Hospital of Nanyang Medical College
NOT_YET_RECRUITING

Nanyang, Henan, 474450, China
The Fourth Affiliated Hospital Of Soochow University (SuZhou Du Shu Lake Hospital)
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215124, China
The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, 050035, China
The People's Hospital of Guizhou Province
NOT_YET_RECRUITING

Guiyang, Guizhou, 550002, China
The Second Affiliated Hospital Of Nangchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital Of Zunyi Medical University
NOT_YET_RECRUITING

Zunyi, Guizhou, 550002, China
The Second Affiliated Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310017, China
The Second Affiliated Hospital of Hainan Medical University
NOT_YET_RECRUITING

Haikou, Hainan, 570311, China
The Second Affiliated Hospital of PLA Air Force Military Medical University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710038, China
The Second Hospital Of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, 230601, China
The Sixth Affiliated Hospital,Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510655, China
The first hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300300, China
Tongji Hospital Tongji Medical College Of Hust
NOT_YET_RECRUITING

Wuhan, Hubei, 430030, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 433000, China
Weifang Yidu Central Hospital
NOT_YET_RECRUITING

Weifang, Shandong, 262500, China
Wenzhou Medical University Affiliated First Hospital
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325000, China
West China Hospital,Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Xijing Hospital
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710032, China
Xuzhou central hospital
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221000, China
Yuncheng Central Hospital
NOT_YET_RECRUITING

Yuncheng, Shanxi, 044000, China
Yunnan Cancer Hospital
NOT_YET_RECRUITING

Kunming, Yunnan, 650000, China
ZhongShan Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200030, China

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