Scientists target aggressive cancers that defy standard drugs

NCT ID NCT04826341

First seen Oct 31, 2025 · Last updated Apr 18, 2026 · Updated 19 times

Summary

This study is testing whether a combination of two drugs, sacituzumab govitecan and berzosertib, can help shrink tumors in people with aggressive cancers that have stopped responding to standard treatments. It is for adults with specific cancers, including small cell lung cancer and other tumors resistant to a common type of drug called a PARP inhibitor. The main goals are to find a safe dose and see if the combination causes tumors to shrink.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.