New cocktail of drugs takes on Hard-to-Treat myeloma
NCT ID NCT05372354
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial is testing several new drug combinations, including an experimental drug called CC-92480, in people with multiple myeloma that has come back or stopped responding to treatment. The main goals are to check safety and find the right doses. About 260 participants will be enrolled across multiple sites. If the combinations show promise, they could offer new options for controlling this blood cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CC-92480 (BMS-986348) combined with other drugs (tazemetostat, BMS-986158, trametinib, dexamethasone)
What this could lead to
If successful, this could point toward new treatment options for people with multiple myeloma that has stopped responding to standard therapies.
What could go wrong
This is an early-phase trial (Phase 1b/2a) with a small number of participants, so the results may not lead to a proven treatment. The drug combinations may cause side effects or fail to control the cancer.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Alberta Health Services AHS - Foothills Medical Centre FMC
RECRUITINGCalgary, Alberta, T2N 5G2, Canada
Contact Phone: •••-•••-••••
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Churchill Hospital
RECRUITINGOxford, Oxfordshire, OX3 7LE, United Kingdom
Contact Phone: •••-•••-••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-••••
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
Contact Phone: •••-•••-••••
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Hospital Universitario Marques de Valdecilla
RECRUITINGSantander, 39008, Spain
Contact Phone: •••-•••-••••
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ICO - Hospital Germans Trias i Pujol
RECRUITINGBarcelona, 08026, Spain
Contact Phone: •••-•••-••••
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John Theurer Cancer Center at Hackensack UMC
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-••••
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Johns Hopkins Medicine - The Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-••••
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Local Institution - 0001
WITHDRAWNLeicester, Leicestershire, LE1 5WW, United Kingdom
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Local Institution - 0014
WITHDRAWNLiverpool, Merseyside, L7 8YA, United Kingdom
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10021, United States
Contact
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NIHR UCLH Clinical Research Facility
RECRUITINGLondon, W1T 7HA, United Kingdom
Contact Phone: •••-•••-••••
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Oslo University Hospital
RECRUITINGOslo, Outside US and Canada, 0450, Norway
Contact Phone: •••-•••-••••
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The Christie NHS Foundation Trust
RECRUITINGManchester, Greater Manchester, M20 4BX, United Kingdom
Contact Phone: •••-•••-••••
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UAB Comprehensive Cancer Center
RECRUITINGBirmingham, Alabama, 35249, United States
Contact Phone: •••-•••-••••
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University Health Network UHN - Princess Margaret Hospital PMH
RECRUITINGToronto, Ontario, M5G 2M9, Canada
Contact Phone: •••-•••-••••
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University of Alberta - Cross Cancer Institute
RECRUITINGEdmonton, Alberta, T6G 1Z2, Canada
Contact Phone: •••-•••-••••