Spinal injection combo shows promise for Tough-to-Treat brain metastases
NCT ID NCT05598853
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 20 times
Summary
This early-phase study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) directly into the spinal fluid, along with the same drugs through an IV, is safe and effective for people with lung cancer or melanoma that has spread to the lining of the brain. The trial enrolls 26 adults with newly diagnosed leptomeningeal metastases. The main goal is to find the best dose and see if the treatment can control the disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University Hospital Basel
Basel, Switzerland
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University Hospital Geneva
Geneva, Switzerland
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University Hospital Zurich
Zurich, Canton of Zurich, Switzerland
Conditions
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